New secondary metabolites from marine-derived fungi and their biological activities

Abstract

New secondary metabolites from marine-derived fungi and their biological activities

Hee Jae Shin1,2,*, Hwa-Sun Lee1, Cao Van Anh1,2, Min Ah Lee1, and Chang-Su Heo1,2

1Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science Technology, 385 Haeyang-ro, Yeongdo-gu, Busan 49111, Korea 2Department of Marine Biotechnology, University of Science and Technology, 217 Gajungro, Yuseong-gu, Daejeon, Republic of Korea

*E-mail: shinhj@kiost.ac.kr

Marine fungi have been studied since the first record of the species Sphaeria posidoniae (Halotthia posidoniae) on the rhizome of the sea grass Posidonia oceanica in 1846 [1], but they have largely been neglected, even though it is estimated that there are greater than 10,000 marine fungal species. Marine fungi are an important source of secondary metabolites useful for drug discovery. Even though marine fungi are less explored in comparison to their terrestrial counterparts, a number of useful hits have been obtained from the drug discovery perspective, adding to their importance in natural product discovery [2].

In our ongoing study on the biomedical potential of marine-derived fungi, we have isolated lots of novel bioactive metabolites from marine fungi isolated from deep-sea and various marine environments. This presentation will highlight the importance of marine-derived fungi in drug discovery from marine natural products. The isolation, structure determination, and bioactivities of novel compounds from marine-derived fungi will be presented.

References 1. Montagne, C. Exploration scientifique de l’Algérie pendant les années 1840, 1841, 1842. (Durieu De Maisonneuve, M.C. Ed), Paris, Imprimerie Royale, 1846; pp. 1- 197. 2. Butler, M.S.; Robertson, A.A.; Cooper, M.A. Natural product and natural product derived drugs in clinical trials. Nat. Prod. Rep. 2014, 31, 1612–1661.