Efficacy of White Spot Syndrome Virus Protein VP28-Expressing Chlorella vulgaris as an Oral Vaccine for Shrimp SCIE SCOPUS
DC Field | Value | Language |
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dc.contributor.author | Kim, Min-Jeong | - |
dc.contributor.author | Kim, Su-Hyun | - |
dc.contributor.author | Kim, Jong-Oh | - |
dc.contributor.author | Lee, Taek Kyun | - |
dc.contributor.author | Jang, In-Kwon | - |
dc.contributor.author | Choi, Tae-Jin | - |
dc.date.accessioned | 2023-10-13T07:30:06Z | - |
dc.date.available | 2023-10-13T07:30:06Z | - |
dc.date.created | 2023-09-28 | - |
dc.date.issued | 2023-10 | - |
dc.identifier.issn | 1999-4915 | - |
dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/44673 | - |
dc.description.abstract | The white spot syndrome virus (WSSV) is the causative agent of white spot disease, which kills shrimp within a few days of infection. Although WSSV has a mortality rate of almost 100% and poses a serious threat to the shrimp farming industry, strategies for its prevention and treatment are extremely limited. In this study, we examined the efficacy of VP28, a recombinant WSSV protein expressed in Chlorella vulgaris (C. vulgaris), as an oral shrimp vaccine. When compared with the control group, in which WSSV had a cumulative mortality of 100%, shrimp treated with 5% VP28-expressing C. vulgaris in their feed only had a 20% cumulative mortality rate 12 days after the WSSV challenge. When compared with the nonvaccinated group, the transcription of anti-lipopolysaccharide factor, C-type lectin, and prophenoloxidase genes, which are involved in shrimp defense against WSSV infection, was upregulated 29.6 fold, 15.4 fold, and 11.5 fold, respectively. These findings highlight C. vulgaris as a potential host for industrial shrimp vaccine production. | - |
dc.description.uri | 1 | - |
dc.language | English | - |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | - |
dc.title | Efficacy of White Spot Syndrome Virus Protein VP28-Expressing Chlorella vulgaris as an Oral Vaccine for Shrimp | - |
dc.type | Article | - |
dc.citation.title | Viruses | - |
dc.citation.volume | 15 | - |
dc.citation.number | 10 | - |
dc.contributor.alternativeName | 이택견 | - |
dc.identifier.bibliographicCitation | Viruses, v.15, no.10 | - |
dc.identifier.doi | 10.3390/v15102010 | - |
dc.identifier.scopusid | 2-s2.0-85175202269 | - |
dc.identifier.wosid | 001094260200001 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.subject.keywordPlus | ANTILIPOPOLYSACCHARIDE FACTOR | - |
dc.subject.keywordPlus | PENAEUS-MONODON | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordPlus | IMMUNITY | - |
dc.subject.keywordPlus | SYSTEM | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | PCR | - |
dc.subject.keywordAuthor | WSSV | - |
dc.subject.keywordAuthor | VP28 | - |
dc.subject.keywordAuthor | vaccine | - |
dc.subject.keywordAuthor | Chlorella vulgaris | - |
dc.subject.keywordAuthor | immunization | - |
dc.relation.journalWebOfScienceCategory | Virology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Virology | - |