Sublethal effects of acetaminophen exposure on benthic aquatic animal (Hydra magnipapillata) SCIE SCOPUS KCI

Cited 0 time in WEB OF SCIENCE Cited 0 time in Scopus
Title
Sublethal effects of acetaminophen exposure on benthic aquatic animal (Hydra magnipapillata)
Author(s)
Yamindago, Ade; Jo, Ye Jin; Won, Hyokyoung; Yum, Seung Shic
KIOST Author(s)
Jo, Ye Jin(조예진)Won, Hyokyoung(원효경)Yum, Seung Shic(염승식)
Alternative Author(s)
조예진; 원효경; 염승식
Publication Year
2023-09
Abstract
Background: Acetaminophen (APAP) is widely used to alleviate pain and fever in human. It is one of the drugs most commonly detected in the environment, and a potential threat to aquatic organisms. This study provides valuable insight into the possible toxic effects of APAP in aquatic organisms. Objective: The adverse effects of APAP were investigated in a benthic animal, Hydra magnipapillata. Results: We found that although APAP did not induce lethal effect on the animal, it did inhibit regeneration of the tentacles at the minimum concentration of 150 mg/L, while it showed no effect on the regeneration of the hypostome. The median inhibitory concentrations (IC50) for tentacles regeneration in H. magnipapillata for (72 and 96) h were (231.3 and 487.9) mg/L, respectively. Gene expression level changes in the exposed H. magnipapillata showed that the genes were mostly upregulated, and APAP could induce oxidative stress, DNA damage, protein damage, genomic instability, gametogenesis disorder, and abnormal morphogenesis. Conclusion: Toxicity level of APAP in H. magnipapillata is relatively low, and showed non-lethal effects. However, at relatively high concentration, APAP could inhibit the regeneration of tentacles that may affect its life abilities. At relatively low concentration, APAP exposure induces various physiological effects that may affects its reproductive activity and morphological development.
ISSN
1738-642X
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/44560
DOI
10.1007/s13273-023-00392-9
Bibliographic Citation
Molecular & Cellular Toxicology, 2023
Publisher
대한독성 유전단백체 학회
Keywords
Analgesic; Genotoxicity; Inhibitory effect; Microarray; Reproductive effects
Type
Article
Language
English
Document Type
Article; Early Access
Files in This Item:
There are no files associated with this item.

qrcode

Items in ScienceWatch@KIOST are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse