Streptopyrrolidine, an angiogenesis inhibitor from a marine-derived Streptomyces sp KORDI-3973
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Title
- Streptopyrrolidine, an angiogenesis inhibitor from a marine-derived Streptomyces sp KORDI-3973
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Author(s)
- Shin, Hee Jae; Kim, Tae Sik; Lee, Hyi-Seung; Park, Jung Youl; Choi, In-Kwon; Kwon, Ho Jeong
- KIOST Author(s)
- Shin, Hee Jae(신희재); Lee, Hyi Seung(이희승)
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Alternative Author(s)
- 신희재; 이희승
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Publication Year
- 2008-09
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Abstract
- Streptopyrrolidine, a benzyl pyrrolidine derivative, was isolated as an angiogenesis inhibitor from the fermentation broth of a marine Streptomyces sp. isolated from the deep sea sediment. its structure was elucidated by extensive 2D NMR and mass spectroscopic analyses. Streptopyrrolidine exhibited significant anti-angiogenesis activity. (C) 2008 Elsevier Ltd. All rights reserved.
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ISSN
- 0031-9422
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/4452
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DOI
- 10.1016/j.phytochem.2008.05.020
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Bibliographic Citation
- PHYTOCHEMISTRY, v.69, no.12, pp.2363 - 2366, 2008
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Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
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Subject
- ACID; (S)-4-HYDROXY-2-PYRROLIDINONE
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Keywords
- Streptomyces sp KORDI-3973; angiogenesis inhibitors; streptopyrrolidine; 5-benzyl-4-hydroxypyrrolidin-2-one; bioactive natural products
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Type
- Article
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Language
- English
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Document Type
- Article
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