Antioxidant Effect from the Viscera peptides of Turbo cornutus

Antioxidant Effect from the Viscera peptides of Turbo cornutus
Kim, Jun Seong; Heo, Seong Yeong; Kang, Na Lae; Kim, Eun A; Heo, Soo Jin
KIOST Author(s)
Kim, Jun Seong(김준성)Heo, Seong Yeong(허성영)Kang, Na Lae(강나래)Kim, Eun A(김은아)Heo, Soo Jin(허수진)
Alternative Author(s)
김준성; 허성영; 강나래; 김은아; 허수진
Publication Year
This study identified potential antioxidant properties from Turbo Cornutus viscera parts. Diverse hydrolysates were evaluated for their hydrogen peroxide (H2O2) scavenging activities. T. cornutus viscera protamex-assisted hydrolysates (TVPH) were purified by gel filtration chromatography (GFC), and potential antioxidant properties were analyzed for their amino acid sequences and its peroxidase inhibition effects by in silico analysis. According to the results, T. cornutus viscera parts are composed of many protein contents with each over 50%. Among the hydrolysates, TVPH possessed the highest H2O2 scavenging activity. Also, TVPH-GFC-3 significantly decreased intracellular reactive oxygen species (ROS) levels and increased cell viability in H2O2-treated HepG2 cells without noncytotoxicity. TVPH-GFC-3 comprises nine low molecular bioactive peptides (ELR, VGPQ, TDY, ALPHA, PAH, VDY, WSDK, VFSP, and FAPQY). Notably, in silico analysis predicted that these bioactive peptides dock to the active site of myeloperoxidase (MPO) with more stable binding energy than 4-aminobenzoic acid hydrazide (4-ABH), an inhibitor of MPO.
Bibliographic Citation
2022 KFN International Symposium and Annual Meeting, 2022
Files in This Item:
There are no files associated with this item.


Items in ScienceWatch@KIOST are protected by copyright, with all rights reserved, unless otherwise indicated.