Cytoprotective Polyketides from Sponge-Derived Fungus Lopadostoma pouzarii SCIE SCOPUS

Cited 2 time in WEB OF SCIENCE Cited 2 time in Scopus
Title
Cytoprotective Polyketides from Sponge-Derived Fungus Lopadostoma pouzarii
Author(s)
Trinh, Phan Thi Hoai; Yurchenko, Anton N.; Khmel, Olga O.; Dieu, Trang Vo Thi; Ngoc, Ngo Thi Duy; Girich, Elena V.; Menshov, Alexander S.; Kim, Natalya Y.; Chingizova, Ekaterina A.; Van, Tran Thi Thanh; Lee, Jong Seok; Lee, Hyi Seung; Yurchenko, Ekaterina A.
KIOST Author(s)
Lee, Jong Seok(이종석)Lee, Hyi Seung(이희승)
Alternative Author(s)
이종석; 이희승
Publication Year
2022-11
Abstract
The new polyketides lopouzanones A and B, as well as the new 1-O-acetyl and 2-O-acetyl derivatives of dendrodochol B, were isolated from the sponge-derived marine fungus Lopadostoma pouzarii strain 168CLC-57.3. Moreover, six known polyketides, gliorosein, balticolid, dendrodolide G, dihydroisocoumarine, (–)-5-methylmellein, and dendrodochol B, were identified. The structures of the isolated compounds were determined by a combination of NMR and ESIMS techniques. The absolute configurations of the lopouzanones A and B were determined using the Mosher’s method. The cytotoxicity of the isolated compounds against human prostate cancer cells PC-3 and normal rat cardiomyocytes H9c2 was investigated. Gliorosein showed weak DPPH radical-scavenging activity and in vitro cardioprotective effects toward rotenone toxicity and CoCl2-mimic hypoxia.
ISSN
1420-3049
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/43400
DOI
10.3390/molecules27217650
Bibliographic Citation
Molecules, v.27, no.21, pp.7650, 2022
Publisher
Multidisciplinary Digital Publishing Institute (MDPI)
Keywords
marine fungi; Lopadostoma pouzarii; sea sponge; secondary metabolites; polyketides; cytotoxicity; cardioprotection
Type
Article
Language
English
Document Type
Article
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