Cytoprotective Polyketides from Sponge-Derived Fungus Lopadostoma pouzarii
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Title
- Cytoprotective Polyketides from Sponge-Derived Fungus Lopadostoma pouzarii
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Author(s)
- Trinh, Phan Thi Hoai; Yurchenko, Anton N.; Khmel, Olga O.; Dieu, Trang Vo Thi; Ngoc, Ngo Thi Duy; Girich, Elena V.; Menshov, Alexander S.; Kim, Natalya Y.; Chingizova, Ekaterina A.; Van, Tran Thi Thanh; Lee, Jong Seok; Lee, Hyi Seung; Yurchenko, Ekaterina A.
- KIOST Author(s)
- Lee, Jong Seok(이종석); Lee, Hyi Seung(이희승)
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Alternative Author(s)
- 이종석; 이희승
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Publication Year
- 2022-11
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Abstract
- The new polyketides lopouzanones A and B, as well as the new 1-O-acetyl and 2-O-acetyl derivatives of dendrodochol B, were isolated from the sponge-derived marine fungus Lopadostoma pouzarii strain 168CLC-57.3. Moreover, six known polyketides, gliorosein, balticolid, dendrodolide G, dihydroisocoumarine, (–)-5-methylmellein, and dendrodochol B, were identified. The structures of the isolated compounds were determined by a combination of NMR and ESIMS techniques. The absolute configurations of the lopouzanones A and B were determined using the Mosher’s method. The cytotoxicity of the isolated compounds against human prostate cancer cells PC-3 and normal rat cardiomyocytes H9c2 was investigated. Gliorosein showed weak DPPH radical-scavenging activity and in vitro cardioprotective effects toward rotenone toxicity and CoCl2-mimic hypoxia.
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ISSN
- 1420-3049
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/43400
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DOI
- 10.3390/molecules27217650
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Bibliographic Citation
- Molecules, v.27, no.21, pp.7650, 2022
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Publisher
- Multidisciplinary Digital Publishing Institute (MDPI)
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Keywords
- marine fungi; Lopadostoma pouzarii; sea sponge; secondary metabolites; polyketides; cytotoxicity; cardioprotection
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Type
- Article
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Language
- English
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Document Type
- Article
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