Transcriptional and toxic responses to saxitoxin exposure in the marine copepod Tigriopus japonicus
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Title
- Transcriptional and toxic responses to saxitoxin exposure in the marine copepod Tigriopus japonicus
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Author(s)
- Kang, Hye Min; Lee, Ji Hoon; Lee, Yeon Ju; Park, Ye Un; Lee, Eui Hyeon; Shin, A Young; Han, Jeong Hoon; Lee, Hyi Seung; Lee, Jong Seok; Lee, Kyun Woo
- KIOST Author(s)
- Kang, Hye Min(강혜민); Lee, Ji Hoon(이지훈); Lee, Yeon Ju(이연주); Park, Ye Un(박예은); Lee, Eui Hyeon(이의현); Jeonghoon, Han(한정훈); Lee, Hyi Seung(이희승); Lee, Jong Seok(이종석); Lee, Kyun Woo(이균우)
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Alternative Author(s)
- 강혜민; 이지훈; 이연주; 박예은; 이의현; 신아영; 한정훈; 이희승; 이종석; 이균우
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Publication Year
- 2022-12
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Abstract
- Saxitoxin (STX) is a highly toxic marine neurotoxin produced by phytoplankton and a growing threat to ecosystems worldwide due to the spread of toxic algae. Although STX is an established sodium channel blocker, the overall profile of transcriptional levels in STX-exposed organisms has yet to be described. Here, we describe a toxicity assay and transcriptome analysis of the copepod Tigriopus japonicus exposed to STX. The half-maximal lethal concentration of STX was 12.35 μM, and a rapid mortality slope was evident at concentrations between 12 and 13 μM. STX induced changes in swimming behavior among the copepods after 10 min of exposure. In transcriptome analysis, gene ontology revealed that the genes involved in nervous system and gene expression were highly enriched. In addition, the congenital neurological disorder and nuclear factor erythroid 2-related factor 2–mediated oxidative stress pathways were identified to be the most significant in network analysis and toxicity pathway analysis, respectively. This study provides valuable information about the effects of STX and related transcriptional responses in T. japonicus. © 2022
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ISSN
- 0045-6535
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/43265
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DOI
- 10.1016/j.chemosphere.2022.136464
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Bibliographic Citation
- Chemosphere, v.309, 2022
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Publisher
- Pergamon Press Ltd.
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Keywords
- Copepod; Marine toxin; Nervous system; Paralytic shellfish poisoning; Saxitoxin
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Type
- Article
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Language
- English
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Document Type
- Article
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