Effect of phlorotannins isolated from Ecklonia cava on melanogenesis and their protective effect against photo-oxidative stress induced by UV-B radiation SCIE SCOPUS

Cited 169 time in WEB OF SCIENCE Cited 189 time in Scopus
Title
Effect of phlorotannins isolated from Ecklonia cava on melanogenesis and their protective effect against photo-oxidative stress induced by UV-B radiation
Author(s)
Heo, Soo-Jin; Ko, Seok-Chun; Cha, Seon-Heui; Kang, Do-Hyung; Park, Heung-Sik; Choi, Young-Ung; Kim, Daekyung; Jung, Won-Kyo; Jeon, You-Jin
KIOST Author(s)
Heo, Soo Jin(허수진)Kang, Do-Hyung(강도형)Park, Heung-Sik(박흥식)
Publication Year
2009-09
Abstract
In the present study, three kinds of phlorotannins, marine algal polyphenol, were isolated from a brown alga Ecklonia cava, and their inhibitory effect on melanogenesis as well as the protective effect against photo-oxidative stress induced by UV-B radiation was investigated. The effect on melanogenesis was evaluated via the inhibitory effects of tyrosinase and melanin synthesis. Among the phlorotannins, dieckol showed higher effect than that of the other phlorotannins in the both assays; especially the value of dieckol in the tyrosinase inhibition assay was relatively higher than that of a commercial tyrosinase inhibitor (kojic acid). The UV-B protection effect was evaluated via DCFH-DA, MITT, comet assays, and morphological changes in fibroblast. Intracellular ROS induced by UV-B radiation was reduced by the addition of phlorotannins and cell viability was dose-dependently increased. Moreover, dieckol demonstrated strong protective properties against UV-B radiation-induced DNA damage via damaged tail intensity and morphological changes in fibroblast. Hence, these results indicated that dieckol isolated from E cava has potential whitening effects and prominent protective effects on UV-B radiation-induced cell damages, which might be used in pharmaceutical and cosmeceutical industries. Crown Copyright (C) 2009 Published by Elsevier Ltd. All rights reserved.
ISSN
0887-2333
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/4264
DOI
10.1016/j.tiv.2009.05.013
Bibliographic Citation
TOXICOLOGY IN VITRO, v.23, no.6, pp.1123 - 1130, 2009
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Subject
MARINE BROWN ALGA; IN-VITRO; ANTIOXIDANT ACTIVITIES; DNA-DAMAGE; OXIDATIVE STRESS; TYROSINASE; SEAWEEDS; CELLS; SKIN; PROLIFERATION
Keywords
Phlorotannin; Dieckol; Ecklonia cova; Melanogenesis; UV-B protection
Type
Article
Language
English
Document Type
Article
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Related Researcher
Research Interests

Marine ecology,Marine biology,Marine living resources,해양생태,해양생물 생리,해양생물자원

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