A new triterpenoid from the stems of Kadsura coccinea with antiproliferative activity
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Title
- A new triterpenoid from the stems of Kadsura coccinea with antiproliferative activity
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Author(s)
- Tram, Le Huyen; Thu Huong, Tran; Thi Thuy, Le; Van Thong, Nguyen; Tuan Anh, Nguyen; Hoang Minh, Nguyen; Thu Ha, Tran; Anh Dung, Dao; Thao, Nguyen Phuong; Thuong, Phuong Thien; Le, Duc Dat; Hiep, Nguyen Dinh; Shin, Hee Jae
- KIOST Author(s)
- Shin, Hee Jae(신희재)
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Alternative Author(s)
- 신희재
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Publication Year
- 2022-05
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Abstract
- A series of schiartane C-29 nortriterpenoids with 5/5/7/6/5 membered consecutive rings (1-5) with an unique schinortriterpenoid skeleton including a new, kadcoccilactone V (1), together with four known ones (2-5) and three known triterpenoids (6-8) were identified from stems of Kadsura coccinea (Lem.) A. C. Smith. The structures of 1 and known compounds were elucidated by interpretation of 1D and 2D NMR, and HR-ESI-MS data as well as comparing those data in the literature. All the isolated compounds were examined for cytotoxic effects against six human cancer cell lines [(HCT-15 (colon), NUGC-3 (stomach), NCI-H23 (lung), ACHN (renal), PC-3 (prostate), and MDA-MB-231 (breast)]. Among them, compound 6 showed potent cytotoxicity against NCI-H23 (GI(50) 1.28 mu M) and NUGC-3 (GI(50) 1.28 mu M), and significantly inhibited on PC-3, MDA-MB-231, ACHN, HCT-15 with GI(50) values around 2.33 to 2.67 mu M.
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ISSN
- 1478-6419
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/42245
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DOI
- 10.1080/14786419.2021.1914612
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Bibliographic Citation
- Natural Product Research, v.36, no.10, pp.2542 - 2546, 2022
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Publisher
- Taylor & Francis
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Keywords
- Kadsura coccinea; Schisandraceae; triterpene; human cancer cells; antiproliferative activity
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Type
- Article
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Language
- English
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Document Type
- Article; Early Access
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