Dieckol induces cell cycle arrest by down-regulating CDK2/cyclin E in response to p21/p53 activation in human tracheal fibroblasts SCIE SCOPUS
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Heo, Seong-Yeong | - |
dc.contributor.author | Jeong, Min-Seon | - |
dc.contributor.author | Lee, Hyoung Shin | - |
dc.contributor.author | Park, Won Sun | - |
dc.contributor.author | Choi, Il-Whan | - |
dc.contributor.author | Yi, Myunggi | - |
dc.contributor.author | Jung, Won-Kyo | - |
dc.date.accessioned | 2022-01-19T10:39:27Z | - |
dc.date.available | 2022-01-19T10:39:27Z | - |
dc.date.created | 2021-11-08 | - |
dc.date.issued | 2022-01 | - |
dc.identifier.issn | 0263-6484 | - |
dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/42240 | - |
dc.description.abstract | The phlorotannin derivative dieckol isolated from Ecklonia cava has been shown to exhibit anti-inflammatory, anti-bacterial, anti-oxidative anti-adipogenic and anti-stenosis activity. However, the role of dieckol in cyclin-dependent kinase 2 (CDK2)/cyclin E signalling, which regulates fibrosis development, has not yet been determined. In this study, we report that dieckol-suppressed cell proliferation through the cell cycle arrest of Hs680.Tr human tracheal fibroblasts. Following consecutive purification, dieckol was identified as a potent bioactive compound. The results showed that dieckol had significant anti-proliferative activity against Hs680.Tr human tracheal fibroblastsWestern blotting analysis also found that dieckol dose-dependently induced the cell cycle arrest of Hs680.Tr fibroblasts in the G0/G1 phase, accompanied by the downregulation of CDK2 and cyclin E and the upregulation of p21 and p53. As attested by molecular docking study, the dieckol interacted with the core interface residues in transforming growth factor-beta receptor with high affinity. These findings suggest that dieckol from E. cava inhibits the cell proliferation of Hs680.Tr, potentially through p21- and p53-mediated G0/G1 cell cycle arrest. | - |
dc.description.uri | 1 | - |
dc.language | English | - |
dc.publisher | John Wiley & Sons Inc. | - |
dc.title | Dieckol induces cell cycle arrest by down-regulating CDK2/cyclin E in response to p21/p53 activation in human tracheal fibroblasts | - |
dc.type | Article | - |
dc.citation.endPage | 78 | - |
dc.citation.startPage | 71 | - |
dc.citation.title | Cell Biochemistry and Function | - |
dc.citation.volume | 40 | - |
dc.citation.number | 1 | - |
dc.contributor.alternativeName | 허성영 | - |
dc.identifier.bibliographicCitation | Cell Biochemistry and Function, v.40, no.1, pp.71 - 78 | - |
dc.identifier.doi | 10.1002/cbf.3675 | - |
dc.identifier.scopusid | 2-s2.0-85117910357 | - |
dc.identifier.wosid | 000711730600001 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.subject.keywordPlus | ECKLONIA-CAVA | - |
dc.subject.keywordPlus | RABBIT MODEL | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | ACCUMULATION | - |
dc.subject.keywordPlus | PHLOROTANNIN | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordAuthor | human tracheal fibroblasts | - |
dc.subject.keywordAuthor | cell cycle arrest | - |
dc.subject.keywordAuthor | cyclin E | - |
dc.subject.keywordAuthor | CDK2 complex | - |
dc.subject.keywordAuthor | Dieckol | - |
dc.subject.keywordAuthor | Ecklonia cava | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |