Streptoglycerides E–H, Unsaturated Polyketides from the Marine-Derived Bacterium Streptomyces specialis and Their Anti-Inflammatory Activity SCIE SCOPUS

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Title
Streptoglycerides E–H, Unsaturated Polyketides from the Marine-Derived Bacterium Streptomyces specialis and Their Anti-Inflammatory Activity
Author(s)
Shin, Hee Jae; Heo, Chang-Su; Ann, Cao Van; Yoon, Yeo Dae; Kang, Jong Soon
KIOST Author(s)
Heo, Chang Su(허창수)ANH, CAO VAN(Cao Van Anh)
Alternative Author(s)
신희재; 허창수; Cao Van Anh
Publication Year
2022-01
Abstract
Four new streptoglycerides E–H (1–4), with a rare 6/5/5/-membered ring system, were isolated from a marine-derived actinomycete Streptomyces specialis. The structures of 1–4 were elucidated by detailed analysis of HRESIMS, 1D and 2D NMR data and ECD spectra as well as comparison of their spectroscopic data with those reported in literature. Compounds 1–4 showed significant anti-inflammatory activity by inhibiting lipopolysaccharide (LPS)-induced nitric oxide (NO) production in Raw 264.7 cells with IC50 values ranging from 3.5 to 10.9 µM. Especially, 2 suppressed mRNA expression levels of iNOS and IL-6 without cytotoxicity.
ISSN
1660-3397
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/42043
DOI
10.3390/md20010044
Bibliographic Citation
Marine Drugs, v.20, no.1, 2022
Publisher
Multidisciplinary Digital Publishing Institute (MDPI)
Keywords
marine-derived bacterium; Streptomyces specialis; streptoglycerides; anti-inflammatory
Type
Article
Language
English
Publisher
Multidisciplinary Digital Publishing Institute (MDPI)
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