Differential gene expression profiling in B[k]F-exposed marine medaka,Oryzias javanicus by subtractive hybridization
- Differential gene expression profiling in B[k]F-exposed marine medaka,Oryzias javanicus by subtractive hybridization
- Jeon, H.-Y.; Woo, S.; Won, H.; Kim, B.; Yum, S.
- KIOST Author(s)
- Yum, Seungshic(염승식)
- Benzo[k]fluoranthene (B[k]F) is one of numerous polycyclic aromatic hydrocarbons (PAHs) which is a persistent environmental contaminant in air and water. Upon B[k]F exposure, differential gene expression profiling was conducted in marine medaka fish (Oryzias javanicus) using subtractive hybridization. As a result, forty two differentially expressed candidate genes were induced in B[k]F-exposed fish as compared to control group, and the genes were associated with general metabolism, signal transduction, cell cycle, immune response, cytoskeleton, development, nucleotide/protein binding and some were non-categorized. These identified gene candidates have great potential to be developed as biomarkers for the identification of effects of B[k]F exposure in the environment. The results obtained in this study will offer insight to the physiological change induced by B[k]F exposure and will help assess the molecular mechanisms of B[k]F toxicity. © 2010 The Korean Society of Environmental Risk Assessment and Health Science and Springer.
- Toxicology and Environmental Health Sciences, v.2, no.4, pp.231 - 237, 2010
- Benzo[k]fluoranthene; Differential gene expression; Marine medaka; Oryzias javanicus
- Related Researcher
Marine Genomics,Environmental Genomics,Novel biomaterials,해양생물유전체,생태환경유전체,바이오신소재
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