Protective effects of dieckol isolated from Ecklonia cava against high glucose-induced oxidative stress in human umbilical vein endothelial cells SCIE SCOPUS

Cited 91 time in WEB OF SCIENCE Cited 96 time in Scopus
Title
Protective effects of dieckol isolated from Ecklonia cava against high glucose-induced oxidative stress in human umbilical vein endothelial cells
Author(s)
Lee, Seung-Hong; Han, Ji-Sook; Heo, Soo-Jin; Hwang, Ji-Young; Jeon, You-Jin
KIOST Author(s)
Heo, Soo Jin(허수진)
Publication Year
2010-03
Abstract
The effect of dieckol, one of phlorotannin polyphenol compound purified from Ecklonia cava (E. cava) against high glucose-induced oxidative stress was investigated using human umbilical vein endothelial cells (HUVECs), which is susceptible to oxidative stress. High glucose (30 mM) treatment induced HUVECs cell death, but dieckol, at concentration 10 or 50 mu g/ml, significantly inhibited the high glucose-induced cytotoxicity. Furthermore, treatment with dieckol dose-dependently decreased thiobarbituric acid reactive substances (TBARS), intracellular reactive oxygen species (ROS) generation and nitric oxide level increased by high glucose. In addition, high glucose levels induced the overexpressions of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) and nuclear factor-kappa B (NF-kappa B) proteins in HUVECs, but dieckol treatment reduced the overexpressions of these proteins. These findings indicate that dieckol is a potential therapeutic agent that will reduce the damage caused by hyperglycemia-induced oxidative stress associated with diabetes. (C) 2009 Elsevier Ltd. All rights reserved.
ISSN
0887-2333
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/4136
DOI
10.1016/j.tiv.2009.11.002
Bibliographic Citation
TOXICOLOGY IN VITRO, v.24, no.2, pp.375 - 381, 2010
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Subject
NITRIC-OXIDE SYNTHASE; KAPPA-B ACTIVATION; ANTIOXIDANT ACTIVITIES; LIPID-PEROXIDATION; DIABETES-MELLITUS; LUNG FIBROBLAST; LLC-PK1 CELLS; PEROXYNITRITE; PHLOROTANNINS; DAMAGE
Keywords
Ecklonia cava; Dieckol; High glucose; Oxidative stress; Protective effects
Type
Article
Language
English
Document Type
Article
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Related Researcher
Research Interests

Marine Biotechnology,Marine Natural Products,Bioactivities,해양생물공학,해양천연물학,생리활성

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