Inhibitory effect of diphlorethohydroxycarmalol on melanogenesis and its protective effect against UV-B radiation-induced cell damage
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Title
- Inhibitory effect of diphlorethohydroxycarmalol on melanogenesis and its protective effect against UV-B radiation-induced cell damage
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Author(s)
- Heo, Soo-Jin; Ko, Seok-Chun; Kang, Sung-Myung; Cha, Seon-Heui; Lee, Seung-Hong; Kang, Do-Hyung; Jung, Won-Kyo; Affana, Abu; Oh, Chulhong; Jeon, You-Jin
- KIOST Author(s)
- Heo, Soo Jin(허수진); Kang, Do Hyung(강도형); Oh, Chul Hong(오철홍)
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Alternative Author(s)
- 허수진; 강도형; Abu Affan; 오철홍
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Publication Year
- 2010-05
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Abstract
- In this study, potential inhibitory effect of 21 species of marine algae on melanogenesis was assessed via tyrosinase inhibitory effect. The Ishige okamurae extract tested herein evidenced profound tyrosinase inhibitory effect, compared to that exhibited by other marine algae extracts. Thus, I. okamurae was selected for use in further experiments, and was partitioned with different organic solvents. Profound tyrosinase inhibitory effect was detected in the ethyl acetate fraction, and the active compound was identified as the carmalol derivative, diphlorethohydroxycarmalol (DPHC), which evidenced higher levels of activity than that of commercial whitening agent. Intracellular reactive oxygen species (ROS) induced by ultraviolet (UV)-B radiation was reduced by the addition of DPHC and cell viability was dose-dependently increased. Moreover. DPHC demonstrated strong protective properties against UV-B radiation via damaged DNA tail length and morphological changes in fibroblast. Hence, these results indicate that DPHC isolated from I. okamurae has potential whitening effects and prominent protective effects on UV-B radiation-induced cell damages which might be used in pharmaceutical and cosmeceutical industries. (C) 2010 Elsevier Ltd. All rights reserved.
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ISSN
- 0278-6915
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/4104
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DOI
- 10.1016/j.fct.2010.03.001
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Bibliographic Citation
- FOOD AND CHEMICAL TOXICOLOGY, v.48, no.5, pp.1355 - 1361, 2010
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Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
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Subject
- ECKLONIA-CAVA; OXIDATIVE DAMAGE; ISHIGE-OKAMURAE; DNA-DAMAGE; ANTIOXIDANT; PHLOROTANNINS; CYANOBACTERIUM; STRESS; ACID; INDUCTION
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Keywords
- Phlorotannin; Diphlorethohydroxycarmalol; Ishige okamurae; Melanogenesis; DNA damage; UV-B protection
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Type
- Article
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Language
- English
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Document Type
- Article
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