Inhibitory effect of diphlorethohydroxycarmalol on melanogenesis and its protective effect against UV-B radiation-induced cell damage SCIE SCOPUS

Cited 73 time in WEB OF SCIENCE Cited 79 time in Scopus
Title
Inhibitory effect of diphlorethohydroxycarmalol on melanogenesis and its protective effect against UV-B radiation-induced cell damage
Author(s)
Heo, Soo-Jin; Ko, Seok-Chun; Kang, Sung-Myung; Cha, Seon-Heui; Lee, Seung-Hong; Kang, Do-Hyung; Jung, Won-Kyo; Affana, Abu; Oh, Chulhong; Jeon, You-Jin
KIOST Author(s)
Heo, Soo Jin(허수진)Kang, Do-Hyung(강도형)Oh, Chulhong(오철홍)
Publication Year
2010-05
Abstract
In this study, potential inhibitory effect of 21 species of marine algae on melanogenesis was assessed via tyrosinase inhibitory effect. The Ishige okamurae extract tested herein evidenced profound tyrosinase inhibitory effect, compared to that exhibited by other marine algae extracts. Thus, I. okamurae was selected for use in further experiments, and was partitioned with different organic solvents. Profound tyrosinase inhibitory effect was detected in the ethyl acetate fraction, and the active compound was identified as the carmalol derivative, diphlorethohydroxycarmalol (DPHC), which evidenced higher levels of activity than that of commercial whitening agent. Intracellular reactive oxygen species (ROS) induced by ultraviolet (UV)-B radiation was reduced by the addition of DPHC and cell viability was dose-dependently increased. Moreover. DPHC demonstrated strong protective properties against UV-B radiation via damaged DNA tail length and morphological changes in fibroblast. Hence, these results indicate that DPHC isolated from I. okamurae has potential whitening effects and prominent protective effects on UV-B radiation-induced cell damages which might be used in pharmaceutical and cosmeceutical industries. (C) 2010 Elsevier Ltd. All rights reserved.
ISSN
0278-6915
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/4104
DOI
10.1016/j.fct.2010.03.001
Bibliographic Citation
FOOD AND CHEMICAL TOXICOLOGY, v.48, no.5, pp.1355 - 1361, 2010
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Subject
ECKLONIA-CAVA; OXIDATIVE DAMAGE; ISHIGE-OKAMURAE; DNA-DAMAGE; ANTIOXIDANT; PHLOROTANNINS; CYANOBACTERIUM; STRESS; ACID; INDUCTION
Keywords
Phlorotannin; Diphlorethohydroxycarmalol; Ishige okamurae; Melanogenesis; DNA damage; UV-B protection
Type
Article
Language
English
Document Type
Article
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
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