Protective effect of diphlorethohydroxycarmalol isolated from Ishige okamurae against high glucose-induced-oxidative stress in human umbilical vein endothelial cells
SCIE
SCOPUS
Cited 43 time in
WEB OF SCIENCE
Cited 50 time in
Scopus
-
Title
- Protective effect of diphlorethohydroxycarmalol isolated from Ishige okamurae against high glucose-induced-oxidative stress in human umbilical vein endothelial cells
-
Author(s)
- Heo, Soo-Jin; Hwang, Ji-Young; Choi, Jung-In; Lee, Seung-Hong; Park, Pyo-Jam; Kang, Do-Hyung; Oh, Chulhong; Kim, Dong-Woo; Han, Ji-Sook; Jeon, You-Jin; Kim, Hak-Ju; Choi, Il-Whan
- KIOST Author(s)
- Heo, Soo Jin(허수진); Kang, Do Hyung(강도형); Oh, Chul Hong(오철홍)
-
Alternative Author(s)
- 허수진; 강도형; 오철홍
-
Publication Year
- 2010-06
-
Abstract
- In the present study, the protective effect of diphlorethohydroxycarmalol (DPHC) isolated from Ishige okamurae, a brown algae, on high glucose-induced-oxidative stress was investigated using human umbilical vein endothelial cells (HUVECs). High concentration of glucose (30 mM) treatment induced cytotoxicity whereas DPHC prevented cells from high glucose-induced damage: restoring cell viability was significantly increased. In addition, the lipid peroxidation, intracellular reactive oxygen species (ROS), and nitric oxide (NO) levels induced by high glucose treatment were effectively inhibited by addition of DPHC in a dose-dependent manner. DPHC also suppressed the over-expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) proteins as well as nuclear factor-kappa B (NF-kappa B) activation induced by high glucose in HUVECs. These finding indicate that DPHC might be used as potential pharmaceutical agent which will reduce the damage caused by high glucose-induced-oxidative stress associated with diabetes. (C) 2010 Elsevier Ltd. All rights reserved.
-
ISSN
- 0278-6915
-
URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/4088
-
DOI
- 10.1016/j.fct.2010.02.025
-
Bibliographic Citation
- FOOD AND CHEMICAL TOXICOLOGY, v.48, no.6, pp.1448 - 1454, 2010
-
Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
-
Subject
- POTENT ALPHA-GLUCOSIDASE; NF-KAPPA-B; DIABETES-MELLITUS; NITRIC-OXIDE; POSTPRANDIAL HYPERGLYCEMIA; ANTIOXIDANT ACTIVITIES; LIPID-PEROXIDATION; BROWN-ALGAE; DNA; PHLOROTANNINS
-
Keywords
- Diphlorethohydorxycarmalol; Diabetes; Oxidative stress; High glucose; HUVECs
-
Type
- Article
-
Language
- English
-
Document Type
- Article
- Files in This Item:
-
There are no files associated with this item.
Items in ScienceWatch@KIOST are protected by copyright, with all rights reserved, unless otherwise indicated.