Protective effect of diphlorethohydroxycarmalol isolated from Ishige okamurae against high glucose-induced-oxidative stress in human umbilical vein endothelial cells SCIE SCOPUS

Cited 33 time in WEB OF SCIENCE Cited 37 time in Scopus
Title
Protective effect of diphlorethohydroxycarmalol isolated from Ishige okamurae against high glucose-induced-oxidative stress in human umbilical vein endothelial cells
Author(s)
Heo, Soo-Jin; Hwang, Ji-Young; Choi, Jung-In; Lee, Seung-Hong; Park, Pyo-Jam; Kang, Do-Hyung; Oh, Chulhong; Kim, Dong-Woo; Han, Ji-Sook; Jeon, You-Jin; Kim, Hak-Ju; Choi, Il-Whan
KIOST Author(s)
Heo, Soo Jin(허수진)Kang, Do Hyung(강도형)Oh, Chul Hong(오철홍)
Publication Year
2010-06
Abstract
In the present study, the protective effect of diphlorethohydroxycarmalol (DPHC) isolated from Ishige okamurae, a brown algae, on high glucose-induced-oxidative stress was investigated using human umbilical vein endothelial cells (HUVECs). High concentration of glucose (30 mM) treatment induced cytotoxicity whereas DPHC prevented cells from high glucose-induced damage: restoring cell viability was significantly increased. In addition, the lipid peroxidation, intracellular reactive oxygen species (ROS), and nitric oxide (NO) levels induced by high glucose treatment were effectively inhibited by addition of DPHC in a dose-dependent manner. DPHC also suppressed the over-expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) proteins as well as nuclear factor-kappa B (NF-kappa B) activation induced by high glucose in HUVECs. These finding indicate that DPHC might be used as potential pharmaceutical agent which will reduce the damage caused by high glucose-induced-oxidative stress associated with diabetes. (C) 2010 Elsevier Ltd. All rights reserved.
ISSN
0278-6915
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/4088
DOI
10.1016/j.fct.2010.02.025
Bibliographic Citation
FOOD AND CHEMICAL TOXICOLOGY, v.48, no.6, pp.1448 - 1454, 2010
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Subject
POTENT ALPHA-GLUCOSIDASE; NF-KAPPA-B; DIABETES-MELLITUS; NITRIC-OXIDE; POSTPRANDIAL HYPERGLYCEMIA; ANTIOXIDANT ACTIVITIES; LIPID-PEROXIDATION; BROWN-ALGAE; DNA; PHLOROTANNINS
Keywords
Diphlorethohydorxycarmalol; Diabetes; Oxidative stress; High glucose; HUVECs
Type
Article
Language
English
Document Type
Article
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
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