Fucoxanthin induces apoptosis in human leukemia HL-60 cells through a ROS-mediated Bcl-xL pathway SCIE SCOPUS
DC Field | Value | Language |
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dc.contributor.author | Kim, Kil-Nam | - |
dc.contributor.author | Heo, Soo-Jin | - |
dc.contributor.author | Kang, Sung-Myung | - |
dc.contributor.author | Ahn, Ginnae | - |
dc.contributor.author | Jeon, You-Jin | - |
dc.date.accessioned | 2020-04-20T08:40:03Z | - |
dc.date.available | 2020-04-20T08:40:03Z | - |
dc.date.created | 2020-01-28 | - |
dc.date.issued | 2010-09 | - |
dc.identifier.issn | 0887-2333 | - |
dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/4042 | - |
dc.description.abstract | Fucoxanthin, a natural biologically active substance isolated from Ishige okamurae, evidences antitumor activity in human leukemia cell HL-60 cells via the induction of apoptosis. However, the mechanism underlying fucoxanthin-induced apoptosis in HL-60 cells remains unclear. In this study, we focused on the effect of fucoxanthin induction on the accumulation of reactive oxygen species (ROS), and on the triggering of Bcl-xL signaling pathway in HL-60 cells. We determined that ROS are generated during fucoxanthin-induced cytotoxicity and apoptosis in HL-60 cells, and that N-acetylcysteine (NAC), a ROS scavenger, suppressed fucoxanthin-induced cytotoxicity and apoptosis. Moreover, fucoxanthin-induced the cleavage of caspases -3 and -7, and poly-ADP-ribose polymerase (PARP) and a decrease of Bcl-xL levels, whereas NAC pre-treatment significantly inhibited caspase-3, -7, and PARP cleavage and the reduction in Bcl-xL levels. In this study, it was demonstrated for the first time that fucoxanthin generated ROS and that the accumulation of ROS performed a crucial role in the fucoxanthin-induced Bcl-xL signaling pathway. (C) 2010 Elsevier Ltd. All rights reserved. | - |
dc.description.uri | 1 | - |
dc.language | English | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.subject | PROSTATE-CANCER CELLS | - |
dc.subject | ACTIVATED PROTEIN-KINASE | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | CYCLE ARREST | - |
dc.subject | CARCINOMA-CELLS | - |
dc.subject | DEATH | - |
dc.subject | INDUCTION | - |
dc.subject | CPP32 | - |
dc.subject | CAROTENOIDS | - |
dc.subject | HOMOLOG | - |
dc.title | Fucoxanthin induces apoptosis in human leukemia HL-60 cells through a ROS-mediated Bcl-xL pathway | - |
dc.type | Article | - |
dc.citation.endPage | 1654 | - |
dc.citation.startPage | 1648 | - |
dc.citation.title | TOXICOLOGY IN VITRO | - |
dc.citation.volume | 24 | - |
dc.citation.number | 6 | - |
dc.contributor.alternativeName | 허수진 | - |
dc.identifier.bibliographicCitation | TOXICOLOGY IN VITRO, v.24, no.6, pp.1648 - 1654 | - |
dc.identifier.doi | 10.1016/j.tiv.2010.05.023 | - |
dc.identifier.scopusid | 2-s2.0-77956181267 | - |
dc.identifier.wosid | 000282114400023 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | PROSTATE-CANCER CELLS | - |
dc.subject.keywordPlus | ACTIVATED PROTEIN-KINASE | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | CYCLE ARREST | - |
dc.subject.keywordPlus | CARCINOMA-CELLS | - |
dc.subject.keywordPlus | DEATH | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | CPP32 | - |
dc.subject.keywordPlus | CAROTENOIDS | - |
dc.subject.keywordPlus | HOMOLOG | - |
dc.subject.keywordAuthor | Fucoxanthin | - |
dc.subject.keywordAuthor | Reactive oxygen species | - |
dc.subject.keywordAuthor | Apoptosis | - |
dc.subject.keywordAuthor | Bcl-xL | - |
dc.subject.keywordAuthor | Human leukemia HL-60 cells | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Toxicology | - |