Tumor suppressor QM-like gene from disk abalone (Haliotis discus discus): Molecular characterization and transcriptional analysis upon immune challenge SCIE SCOPUS

DC Field Value Language
dc.contributor.author Oh, Chulhong -
dc.contributor.author Zoysa, Mahanama De -
dc.contributor.author Nikapitiya, Chamilani -
dc.contributor.author Whang, Ilson -
dc.contributor.author Kim, Yu Cheol -
dc.contributor.author Kang, Do-Hyung -
dc.contributor.author Heo, Soo-Jin -
dc.contributor.author Choi, Young-Ung -
dc.contributor.author Choi, Cheol Young -
dc.contributor.author Lee, Jae-Seong -
dc.contributor.author Lee, Jehee -
dc.date.accessioned 2020-04-20T08:40:02Z -
dc.date.available 2020-04-20T08:40:02Z -
dc.date.created 2020-01-28 -
dc.date.issued 2010-09 -
dc.identifier.issn 1050-4648 -
dc.identifier.uri https://sciwatch.kiost.ac.kr/handle/2020.kiost/4040 -
dc.description.abstract We describe molecular characterization and transcriptional analysis of the gene encoding tumor suppressor QM-like protein, AbQM, in the disk abalone nations discus discus. The full-length cDNA (765-bp) of AbQM was found to consist of a 654-bp ORF coding for a 218 amino acid protein of a 25 kDa molecular mass with a 10.2 isoelectric point. Analysis of AbQM sequence revealed the presence of characteristic motifs, including the ribosomal protein L10 signature, SH3-binding motif and two antibiotic binding sites. Phylogenetic analysis confirmed that AbQM is closely related to other mollusk QM proteins, and altogether they form a mollusk QM protein sub-family which displays evolutionary conservation from yeast to human Tissue-specific expression and transcriptional regulation of AbQM was analyzed by quantitative real-time PCR in response to bacterial (Vibrio alginolyticus and Vibrio parahemolyticus, Listeria monocrogenes) and viral (viral hemorrhagic septicemia virus, VHSV) challenge AbQM transcripts were found to be expressed ubiquitously in all examined tissues in a constitutive manner, as similar expression levels were detected in hemocytes, mantle, digestive tract and muscle Upon bacterial and VHSV challenge, AbQM showed significant up-regulation in gills, but not in hemocytes. Taken together, these findings suggest that AbQM in abalone-like mollusks can respond to and facilitate a defensive effect against pathogenic infection. (C) 2010 Elsevier Ltd. All rights reserved. -
dc.description.uri 1 -
dc.language English -
dc.publisher ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD -
dc.subject EXPRESSION ANALYSIS -
dc.subject SEQUENCE ALIGNMENT -
dc.subject PEARL OYSTER -
dc.subject C-JUN -
dc.subject HOMOLOG -
dc.subject PROTEIN -
dc.subject CLONING -
dc.subject STRESS -
dc.subject CELLS -
dc.subject CDNA -
dc.title Tumor suppressor QM-like gene from disk abalone (Haliotis discus discus): Molecular characterization and transcriptional analysis upon immune challenge -
dc.type Article -
dc.citation.endPage 500 -
dc.citation.startPage 494 -
dc.citation.title FISH & SHELLFISH IMMUNOLOGY -
dc.citation.volume 29 -
dc.citation.number 3 -
dc.contributor.alternativeName 오철홍 -
dc.contributor.alternativeName 강도형 -
dc.contributor.alternativeName 허수진 -
dc.contributor.alternativeName 최영웅 -
dc.identifier.bibliographicCitation FISH & SHELLFISH IMMUNOLOGY, v.29, no.3, pp.494 - 500 -
dc.identifier.doi 10.1016/j.fsi.2010.05.007 -
dc.identifier.scopusid 2-s2.0-77954543331 -
dc.identifier.wosid 000280513700015 -
dc.type.docType Article -
dc.description.journalClass 1 -
dc.subject.keywordPlus EXPRESSION ANALYSIS -
dc.subject.keywordPlus SEQUENCE ALIGNMENT -
dc.subject.keywordPlus PEARL OYSTER -
dc.subject.keywordPlus C-JUN -
dc.subject.keywordPlus HOMOLOG -
dc.subject.keywordPlus PROTEIN -
dc.subject.keywordPlus CLONING -
dc.subject.keywordPlus STRESS -
dc.subject.keywordPlus CELLS -
dc.subject.keywordPlus CDNA -
dc.subject.keywordAuthor Abalone Haliotis discus discus -
dc.subject.keywordAuthor Hemocytes -
dc.subject.keywordAuthor Invertebrate -
dc.subject.keywordAuthor QM gene -
dc.subject.keywordAuthor Tumor suppressor -
dc.relation.journalWebOfScienceCategory Fisheries -
dc.relation.journalWebOfScienceCategory Immunology -
dc.relation.journalWebOfScienceCategory Marine & Freshwater Biology -
dc.relation.journalWebOfScienceCategory Veterinary Sciences -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.relation.journalResearchArea Fisheries -
dc.relation.journalResearchArea Immunology -
dc.relation.journalResearchArea Marine & Freshwater Biology -
dc.relation.journalResearchArea Veterinary Sciences -
Appears in Collections:
Jeju Research Institute > Jeju Bio Research Center > 1. Journal Articles
Jeju Research Institute > Tropical & Subtropical Research Center > 1. Journal Articles
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