Dieckol isolated from Ecklonia cava inhibits alpha-glucosidase and alpha-amylase in vitro and alleviates postprandial hyperglycemia in streptozotocin-induced diabetic mice SCIE SCOPUS

Cited 115 time in WEB OF SCIENCE Cited 134 time in Scopus
Title
Dieckol isolated from Ecklonia cava inhibits alpha-glucosidase and alpha-amylase in vitro and alleviates postprandial hyperglycemia in streptozotocin-induced diabetic mice
Author(s)
Lee, Seung-Hong; Park, Mi-Hwa; Heo, Soo-Jin; Kang, Sung-Myung; Ko, Seok-Chun; Han, Ji-Sook; Jeon, You-Jin
KIOST Author(s)
Heo, Soo Jin(허수진)
Publication Year
2010-10
Abstract
This study was designed to investigate whether dieckol may inhibit alpha-glucosidase and alpha-amylase activities, and alleviate postprandial hyperglycemia in streptozotocin-induced diabetic mice. Dieckol isolated from Ecklonia cava, brown algae, evidenced prominent inhibitory effect against alpha-glucosidase and alpha-amylase. The IC50 values of dieckol against a-glucosidase and alpha-amylase were 0.24 and 0.66 mM, respectively, which evidenced the higher activities than that of acarbose. Dieckol did not exert any cytotoxic effect in human umbilical vein endothelial cells (HUVECs) at various concentrations (from 0.33 to 2.69 mM). The increase of postprandial blood glucose levels were significantly suppressed in the dieckol administered group than those in the streptozotocin-induced diabetic or normal mice. Moreover, the area under curve (AUC) was significantly reduced via dieckol administration (259 versus 483 mmol min/l) in the diabetic mice as well as it delays absorption of dietary carbohydrates. Therefore, these result indicated that dieckol might be a potent inhibitor for a-glucosidase and alpha-amylase. (C) 2010 Elsevier Ltd. All rights reserved.
ISSN
0278-6915
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/4027
DOI
10.1016/j.fct.2010.06.032
Bibliographic Citation
FOOD AND CHEMICAL TOXICOLOGY, v.48, no.10, pp.2633 - 2637, 2010
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Subject
ANTIOXIDANT ACTIVITIES; OXIDATIVE STRESS; LUNG FIBROBLAST; ACARBOSE; ALGAE
Keywords
Ecklonia cava; Dieckol; alpha-Glucosidase; alpha-Amylase; Postprandial hyperglycemia; Diabetic mice
Type
Article
Language
English
Document Type
Article
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Related Researcher
Research Interests

Marine Biotechnology,Marine Natural Products,Bioactivities,해양생물공학,해양천연물학,생리활성

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