Effects of Balneotherapy in Jeju Magma-Seawater on Knee Osteoarthritis Model SCIE SCOPUS

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Title
Effects of Balneotherapy in Jeju Magma-Seawater on Knee Osteoarthritis Model
Author(s)
Kim C.-G.; Lee D.-G.; Oh J.; Lee Y.-H.; Lee Y.J.; Song P.H.; Song C.-H.; Ku S.-K.
KIOST Author(s)
Kim, Choong Gon(김충곤)Lee, Youn Ho(이윤호)
Publication Year
2020-04
Abstract
Balneotherapy is a common non-pharmacological treatment for osteoarthritis (OA), however, the efficacy is controversial in knee OA. Jeju magma-seawater (JMS) has high contents of various minerals, which has anti-inflammatory and antioxidant properties via an oral route. Thus, we examined the effects of JMS bathing on knee OA and the combination effects with diclofenac sodium as an anti-inflammatory drug. Knee OA was induced by transection of the anterior cruciate ligament and the partial meniscectomy in rat. The rats were administered subcutaneously saline or diclofenac sodium in saline, followed by bathing in thermal distilled water or JMS for 8 weeks. The model represented the characteristic changes of the cartilage degradation, osteophyte formation and synovial inflammation, and the relevant symptoms of the joint swelling and stiffness. However, the JMS bathing reduced the joint thickness and improved the mobility. It also contributed to a well-preserved tissue supported by increases in bone mineral density of the joint and decreases in Mankin scores in the cartilages. The effects involved anti-inflammation, chondroprotection, anti-apoptosis, and chondrogenesis. Overall, the JMS bathing in combination with diclofenac sodium showed a similar trend associated with synergic effects. It suggests that JMS bathing can be promising for a clinical use in knee OA.
ISSN
2045-2322
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/40260
DOI
10.1038/s41598-020-62867-2
Bibliographic Citation
Scientific Reports, v.10, no.1, 2020
Publisher
Nature Research
Type
Article
Language
English
Document Type
Article
Publisher
Nature Research
Related Researcher
Research Interests

Marine Molecular Genetics,Marine Ecology and Evolution,해양분자유전,해양생태및진화

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