Bromophenols as Candida albicans isocitrate lyase inhibitors SCIE SCOPUS
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- Title
- Bromophenols as Candida albicans isocitrate lyase inhibitors
- KIOST Author(s)
- Lee, Yeon Ju(이연주); Lee, Hyi Seung(이희승)
- Alternative Author(s)
- 이연주; 이희승
- Publication Year
- 2010-11-15
- Abstract
- A new series of bromophenols was synthesized by reactions of corresponding phenol analogs with bromine. The synthesized compounds were tested for inhibitory activity against isocitrate lyase (ICL) of Candida albicans and antimicrobial activity against Gram-positive and, Gram-negative bacteria and fungi. Among the synthesized bromophenols, bis(3-bromo-4,5-dihydroxyphenyl)methanone (11) and (3-bromo-4,5-dihydroxyphenyl)(2,3-dibromo-4,5-dihydroxyphenyl)methanone (12) displayed potent inhibitory activities against ICL, showing a stronger inhibitory effects than were found with natural bromophenol 1. The preliminary structure-activity relationships were investigated in order to determine the essential structural requirements for the inhibitory activities of these compounds against ICL of C. albicans. (C) 2010 Elsevier Ltd. All rights reserved.
- ISSN
- 0960-894X
- Bibliographic Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.20, no.22, pp.6644 - 6648, 2010
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Subject
- ALGA ODONTHALIA-CORYMBIFERA; ANTIMICROBIAL ACTIVITIES; GLYOXYLATE CYCLE; PATHOGENICITY; ANALOGS; ESTER
- Keywords
- Bromophenols; Synthesis; Isocitrate lyase inhibition; Antibacterial activity; Antifungal activity
- Type
- Article
- Language
- English
- Document Type
- Article
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- There are no files associated with this item.
