Bromophenols as Candida albicans isocitrate lyase inhibitors SCIE SCOPUS

Cited 15 time in WEB OF SCIENCE Cited 16 time in Scopus
Title
Bromophenols as Candida albicans isocitrate lyase inhibitors
Author(s)
Oh, Ki-Bong; Jeon, Heung Bae; Han, Yu-Ri; Lee, Yeon-Ju; Park, Jiyoung; Lee, So-Hyoung; Yang, Dongsik; Kwon, Mihyun; Shin, Jongheon; Lee, Hyi-Seung
KIOST Author(s)
Lee, Yeon Ju(이연주)Lee, Hyi Seung(이희승)
Publication Year
2010-11-15
Abstract
A new series of bromophenols was synthesized by reactions of corresponding phenol analogs with bromine. The synthesized compounds were tested for inhibitory activity against isocitrate lyase (ICL) of Candida albicans and antimicrobial activity against Gram-positive and, Gram-negative bacteria and fungi. Among the synthesized bromophenols, bis(3-bromo-4,5-dihydroxyphenyl)methanone (11) and (3-bromo-4,5-dihydroxyphenyl)(2,3-dibromo-4,5-dihydroxyphenyl)methanone (12) displayed potent inhibitory activities against ICL, showing a stronger inhibitory effects than were found with natural bromophenol 1. The preliminary structure-activity relationships were investigated in order to determine the essential structural requirements for the inhibitory activities of these compounds against ICL of C. albicans. (C) 2010 Elsevier Ltd. All rights reserved.
ISSN
0960-894X
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/4011
DOI
10.1016/j.bmcl.2010.09.015
Bibliographic Citation
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.20, no.22, pp.6644 - 6648, 2010
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Subject
ALGA ODONTHALIA-CORYMBIFERA; ANTIMICROBIAL ACTIVITIES; GLYOXYLATE CYCLE; PATHOGENICITY; ANALOGS; ESTER
Keywords
Bromophenols; Synthesis; Isocitrate lyase inhibition; Antibacterial activity; Antifungal activity
Type
Article
Language
English
Document Type
Article
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
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