New Polyenes from the Marine-Derived Fungus Talaromyces cyanescens with Anti-Neuroinflammatory and Cytotoxic Activities
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Title
- New Polyenes from the Marine-Derived Fungus Talaromyces cyanescens with Anti-Neuroinflammatory and Cytotoxic Activities
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Author(s)
- Shin, Hee Jae; ANH, CAO VAN; Cho, Duk-Yeon; Choi, Dong-Kug; Kang, Jong Soon; Trinh, Phan Thi Hoai; Choi, Byeoung Kyu; Lee, Hwa Sun
- KIOST Author(s)
- Shin, Hee Jae(신희재); Lee, Hwa Sun(이화선)
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Alternative Author(s)
- 신희재; Cao Van Anh; 최병규; 이화선
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Publication Year
- 2021-02
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Abstract
- Three new polyene compounds, talacyanols A-C (1-3), along with two known compounds, ramulosin (4) and eurothiocin A (5), were isolated from the marine fungus Talaromyces cyanescens derived from a seaweed Caulerpa sp. Structures of 1-5 were established by one-dimensional and two-dimensional (1D/2D) NMR, HR-ESIMS, and the modified Mosher's methods, as well as comparison with previously reported literature data. All the compounds (1-5) were tested for their in vitro cytotoxic and anti-neuroinflammatory activities. Among them, 1 showed moderate cytotoxic activity against a panel of cancer cell lines (HCT-15, NUGC-3, NCI-H23, ACHN, PC-3, and MDA-MB-231) with GI(50) values ranging from 44.4 to 91.6 mu M, whereas compounds 2 and 5 exhibited anti-neuroinflammatory effect without cytotoxicity against all the tested cell lines.
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ISSN
- 1420-3049
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/39674
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DOI
- 10.3390/molecules26040836
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Bibliographic Citation
- MOLECULES, v.26, no.4, 2021
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Publisher
- MDPI
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Keywords
- Talaromyces cyanescens; marine-derived fungus; polyenes; cytotoxicity; anti-neuroinflammatory
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Type
- Article
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Language
- English
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Document Type
- Article
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