A Fluorescent Probe for Selective Facile Detection of H2S in Serum Based on an Albumin-Binding Fluorophore and Effective Masking Reagent SCIE SCOPUS
DC Field | Value | Language |
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dc.contributor.author | Lee, Suji | - |
dc.contributor.author | Sung, Dan Bi | - |
dc.contributor.author | Lee, Jong Seok | - |
dc.contributor.author | Han, Min Su | - |
dc.date.accessioned | 2020-12-10T08:03:28Z | - |
dc.date.available | 2020-12-10T08:03:28Z | - |
dc.date.created | 2020-12-10 | - |
dc.date.issued | 2020-12-22 | - |
dc.identifier.issn | 2470-1343 | - |
dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/38913 | - |
dc.description.abstract | A fluorescent probe (4-(2-(4-(diethylamino)-phenyl)-4-methyl-5-oxo-4,5- dihydrothieno [3,2- b]pyridin-7-yl)phenyl 2,4-dinitrobenzenesulfonate, KF-DNBS) for facile detection of H2S in serum was developed based on the combination of an environment-sensitive fluorophore (2-(4-(diethylamino)-phenyl)-7-(4-hydroxyphenyl)-4-methylthieno [3,2b] pyridin-5(4H)-one, KF) with albumin and the 2,4-dinitrobenzene sulfonyl (DNBS) group as a recognition unit for H2S. KF-DNBS showed remarkable fluorescence enhancement due to H2S-triggered thiolysis followed by the formation of a fluorescent fluorophore (KF)-albumin complex. The H2S detection limit of KF-DNBS was estimated to be 3.2 mu M, and KF-DNBS achieves a high selectivity to H2S over biothiols by employing 2-formyl benzene boronic acid (2-FBBA) as an effective masking reagent. Furthermore, under optimized sensing conditions, KF-DNBS could be applied to accurately determine spiked H2S in human serum without the need for any further procedure for the removal of serum proteins. | - |
dc.description.uri | 1 | - |
dc.language | English | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | HYDROGEN-SULFIDE | - |
dc.subject | BLOOD | - |
dc.subject | GASOTRANSMITTER | - |
dc.subject | CYSTEINE | - |
dc.subject | BIOLOGY | - |
dc.subject | SULFUR | - |
dc.subject | HEALTH | - |
dc.title | A Fluorescent Probe for Selective Facile Detection of H2S in Serum Based on an Albumin-Binding Fluorophore and Effective Masking Reagent | - |
dc.type | Article | - |
dc.citation.endPage | 32514 | - |
dc.citation.startPage | 32507 | - |
dc.citation.title | ACS OMEGA | - |
dc.citation.volume | 5 | - |
dc.citation.number | 50 | - |
dc.contributor.alternativeName | 성단비 | - |
dc.contributor.alternativeName | 이종석 | - |
dc.identifier.bibliographicCitation | ACS OMEGA, v.5, no.50, pp.32507 - 32514 | - |
dc.identifier.doi | 10.1021/acsomega.0c04659 | - |
dc.identifier.scopusid | 2-s2.0-85097886162 | - |
dc.identifier.wosid | 000603283500038 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.subject.keywordPlus | HYDROGEN-SULFIDE | - |
dc.subject.keywordPlus | BLOOD | - |
dc.subject.keywordPlus | GASOTRANSMITTER | - |
dc.subject.keywordPlus | CYSTEINE | - |
dc.subject.keywordPlus | BIOLOGY | - |
dc.subject.keywordPlus | SULFUR | - |
dc.subject.keywordPlus | HEALTH | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |