생쥐에서 제주조릿대 잎 잔사 추출물의 고요산 혈증 저감 효과 KCI

Title
생쥐에서 제주조릿대 잎 잔사 추출물의 고요산 혈증 저감 효과
Alternative Title
Protective effects of Sasa quelpaertensis Leaf Residue Extract against Potassium Oxonate-induced Hyperuricemia in Mice
Author(s)
장미경; 송하나; 이주엽; 고희철; 허성표; 김세재
Alternative Author(s)
허성표
Publication Year
2019-01
Abstract
Leaves of Sasa quelpaertensis Nakai are used in folk medicine for their anti-inflammatory, antipyretic, and diuretic properties. To ensure efficient utilization of S. quelpaertensis leaf, we previously reported a preparation method for phytochemical-rich extract (PRE) using the leaf residue, which was produced after hot water extraction. This study was undertaken to evaluate the hypouricemic potential of S. quelpaertensis leaf PRE in potassium oxonate (PO)-induced hyperuricemic mice. The administration of PRE significantly reduced serum uric acid (UA), blood urea nitrogen (BUN), and serum creatinine levels and increased urine UA and creatinine levels in the PO-induced hyperuricemic mice. It also reduced liver UA levels and xanthine oxidase (XA) activity. A histological analysis revealed that PRE administration protected against PO-induced liver damage, pointing to anti-inflammatory and cytoprotective effects in PO-induced hyperuricemic mice. We analyzed the transcriptome response to PRE administration in PO-induced hyperuricemic mice using RNA sequencing (RNA-Seq) in kidney tissues. The administration of PRE mainly enriched genes involved in mediating immune and inflammatory responses and the metabolic pathway. A Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis showed that the metabolic pathway, purine metabolism, and antibody biosynthesis were the major pathways altered in the PRE and PO groups. These results suggest a potential role for PRE in the prevention and treatment of hyperuricemia with inflammation.
ISSN
1225-9918
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/38883
DOI
10.5352/JLS.2019.29.1.37
Bibliographic Citation
생명과학회지, v.29, no.1, pp.37 - 44, 2019
Publisher
한국생명과학회
Keywords
Hyperuricemia; potassium oxonate; RNA sequencing; Sasa quelpaertensis; uric acid
Type
Article
Language
English
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