Acetylthiocholine (ATC) - Cleaving cholinesterase (ChE) activity as a potential biomarker of pesticide exposure in the Manila clam, Ruditapes philippinarum, of Korea
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Title
- Acetylthiocholine (ATC) - Cleaving cholinesterase (ChE) activity as a potential biomarker of pesticide exposure in the Manila clam, Ruditapes philippinarum, of Korea
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Author(s)
- Choi, Jin Young; Yu, Jun; Yang, Dong Beom; Ra, Kongtae; Kim, Kyung Tae; Hong, Gi Hoon; Shin, Kyung Hoon
- KIOST Author(s)
- Choi, Jin Young(최진영); Ra, Kongtae(나공태); Kim, Kyung Tae(김경태)
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Alternative Author(s)
- 최진영; 양동범; 나공태; 김경태; 홍기훈
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Publication Year
- 2011-04
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Abstract
- The acetylthiocholine (ATC) - cleaving cholinesterase (ChE) activity in Manila clam, which is widely distributed throughout the coastal environment of Korea, was assayed as a potentially useful biomarker of organophosphorous pesticides (OPs). A clear dose-response relationship was determined between inhibited ChE in adductor muscle of clams and four OPs (methidathion, chlorpyrifos, diazinon, IBP) which are heavily used OPs in Korea. The measured EC50-24 h values of methidathion, chlorpyrifos, diazinon, and IBP for Ruditapes philippinarum were 7.16 mu g l(-1), 0.34 mg l(-1), 3.01 mg l(-1), and 3.41 mg l(-1), respectively. In field studies, ChE activity in Manila clams collected from 23 stations in the mid-western coastal region demonstrated spatial variation with statistical differences. These results suggest that ChE activity in R. philippinarum is a potential biomarker for assessing organophosphorous pesticide contamination in coastal environments. (C) 2011 Elsevier Ltd. All rights reserved.
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ISSN
- 0141-1136
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/3876
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DOI
- 10.1016/j.marenvres.2010.12.007
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Bibliographic Citation
- MARINE ENVIRONMENTAL RESEARCH, v.71, no.3, pp.162 - 168, 2011
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Publisher
- ELSEVIER SCI LTD
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Subject
- POLYCYCLIC AROMATIC-HYDROCARBONS; ACETYLCHOLINESTERASE ACTIVITY; MYTILUS-GALLOPROVINCIALIS; ADAMUSSIUM-COLBECKI; TAPES-PHILIPPINARUM; CRASSOSTREA-GIGAS; JOINT ACTION; IN-VITRO; EDULIS; INHIBITION
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Keywords
- Cholinesterase; Biomarker; Chlorpyrifos; IBP; Organophosphorous pesticides (OPs); Manila clam; Ruditapes philippinarum
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Type
- Article
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Language
- English
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Document Type
- Article
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