Antioxidant and anti-melanogenic activities of ultrasonic extract from Stichopus japonicus SCIE SCOPUS
DC Field | Value | Language |
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dc.contributor.author | Ding, Yuling | - |
dc.contributor.author | Jiratchayamaethasakul, Chanipa | - |
dc.contributor.author | Kim, Junseong | - |
dc.contributor.author | Kim, Eun-A | - |
dc.contributor.author | Heo, Soo-Jin | - |
dc.contributor.author | Lee, Seung-Hong | - |
dc.date.accessioned | 2020-12-10T07:55:48Z | - |
dc.date.available | 2020-12-10T07:55:48Z | - |
dc.date.created | 2020-05-27 | - |
dc.date.issued | 2020-01 | - |
dc.identifier.issn | 2221-1691 | - |
dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/38758 | - |
dc.description.abstract | Objective: To investigate the antioxidant and anti-melanogenesis activities of an ultrasonic extract of red sea cucumber, Stichopus japonicus, collected from Jeju Island.Methods: Antioxidant activity experiments were assessed by an electron spin resonance system and a cellular model of immortalized human keratinocytes (HaCaT) to determine its radical scavenging activity and protective effects against 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH)-induced oxidative stress. Anti-melanogenic activity of the ultrasonic extract of red sea cucumber was also examined using the melanoma cell model B16F10 and mushroom tyrosinase. Following the induction by alpha-melanocyte-stimulating hormone, the effects of the ultrasonic extract of red sea cucumber on intracellular tyrosinase activity, melanin content and the melanogenic protein expression of microphthalmia-associated transcription factor, tyrosinase, and tyrosinase-related proteins (TRP-1, and TRP-2) were examined.Results: The ultrasonic extract of red sea cucumber significantly scavenged 2,2-diphenyl-1-picrylhydrazyl and alkyl radicals [IC50: (0.924 +/- 0.035) and (0.327 +/- 0.006) mg/mL, respectively], as well as showed a protective effect against oxidative stress and attenuated generation of intracellular reactive oxygen species on AAPH- induced HaCaT cells, with no cytotoxicity (12.5-400 mu g/mL). The ultrasonic extract of red sea cucumber also exhibited a tyrosinase inhibitory effect [IC50: (2.750 +/- 0.006) mg/mL]. On alpha-melanocyte-stimulating hormone-stimulated B16F10 melanoma cells, the ultrasonic extract of red sea cucumber (25-200 mu g/mL) significantly inhibited not only melanin synthesis and tyrosinase activity, but also protein expressions of microphthalmia-associated transcriptional factor, tyrosinase, TRP-1, and TRP-2.Conclusions: The ultrasonic extract of red sea cucumber shows antioxidant and anti-melanogenic potential and may be a natural candidate for anti-aging as well as a whitening agent in the cosmeceuticals industry. | - |
dc.description.uri | 1 | - |
dc.language | English | - |
dc.publisher | WOLTERS KLUWER MEDKNOW PUBLICATIONS | - |
dc.title | Antioxidant and anti-melanogenic activities of ultrasonic extract from Stichopus japonicus | - |
dc.type | Article | - |
dc.citation.endPage | 41 | - |
dc.citation.startPage | 33 | - |
dc.citation.title | ASIAN PACIFIC JOURNAL OF TROPICAL BIOMEDICINE | - |
dc.citation.volume | 10 | - |
dc.citation.number | 1 | - |
dc.contributor.alternativeName | 김준성 | - |
dc.contributor.alternativeName | 김은아 | - |
dc.contributor.alternativeName | 허수진 | - |
dc.identifier.bibliographicCitation | ASIAN PACIFIC JOURNAL OF TROPICAL BIOMEDICINE, v.10, no.1, pp.33 - 41 | - |
dc.identifier.doi | 10.4103/2221-1691.273092 | - |
dc.identifier.scopusid | 2-s2.0-85077634237 | - |
dc.identifier.wosid | 000506819500005 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | EASTERN SEA-CUCUMBER | - |
dc.subject.keywordPlus | ETHANOL EXTRACTS | - |
dc.subject.keywordPlus | ECKLONIA-CAVA | - |
dc.subject.keywordPlus | FRACTIONS | - |
dc.subject.keywordPlus | STRESS | - |
dc.subject.keywordPlus | WATER | - |
dc.subject.keywordAuthor | Anti-melanogenesis | - |
dc.subject.keywordAuthor | Antioxidant activity | - |
dc.subject.keywordAuthor | Cosmeceuticals | - |
dc.subject.keywordAuthor | Red sea cucumber (Stichopus japonicus) | - |
dc.subject.keywordAuthor | Ultrasonic extract | - |
dc.relation.journalWebOfScienceCategory | Tropical Medicine | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Tropical Medicine | - |