Anti-Hypertensive Activity of Novel Peptides Identified from Olive Flounder (Paralichthys olivaceus) Surimi SCIE SCOPUS

Cited 5 time in WEB OF SCIENCE Cited 6 time in Scopus
Title
Anti-Hypertensive Activity of Novel Peptides Identified from Olive Flounder (Paralichthys olivaceus) Surimi
Author(s)
Oh J.-Y.; Je J.-G.; Lee H.-G.; Kim E.-A.; Kang S.I.; Lee J.-S.; Jeon Y.-J.
KIOST Author(s)
Kim, Eun A(김은아)
Publication Year
2020-05
Abstract
There is a growing interest in the health benefits of functional foods. A benefit that has been long sought is the control of hypertension through dietary approaches. Hypertension has been implicated as a risk factor for cardiovascular disease and is therefore of clinical significance. Here, we aim to demonstrate the antihypertensive activity of novel peptides derived from surimi, a functional food ingredient made from refined fish myofibrillar proteins. Three peptides, Ile-Val-Asp-Arg (IVDR), Trp-Tyr-Lys (WYK), and Val-Ala-Ser-Val-Ile (VASVI), were isolated from surimi made from the olive flounder (Paralichthys olivaceus). Our results show that IVDR, WYK, and VASVI exhibited high Angiotensin I-converting Enzyme (ACE) inhibition activity. These peptides are also shown to increase phosphorylation of protein kinase B (Akt) and endothelial nitric oxide synthase (eNOS), and significantly promote nitric oxide (NO) production in human umbilical vein endothelial cells. Oral administration of the peptides decreased blood pressure in spontaneously hypertensive rats (SHRs), thereby confirming that the peptides derived from surimi perform antihypertensive activity via the Akt/eNOS pathway. These results indicate that surimi made from P. olivaceus contains novel antihypertensive peptides that could be used to enhance the health benefits of food ingredients.
ISSN
2304-8158
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/38668
DOI
10.3390/foods9050647
Bibliographic Citation
FOODS, v.9, no.5, 2020
Publisher
MDPI
Keywords
antihypertensive; peptide; Paralichthys olivaceus; surimi
Type
Article
Language
English
Document Type
Article
Publisher
MDPI
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