Macrolactin W, a new antibacterial macrolide from a marine Bacillus sp. SCIE SCOPUS

Cited 35 time in WEB OF SCIENCE Cited 40 time in Scopus
Title
Macrolactin W, a new antibacterial macrolide from a marine Bacillus sp.
Author(s)
Mondol, M. A. Mojid; Kim, Ji Hye; Lee, Hyi-Seung; Lee, Yeon-Ju; Shin, Hee Jae
KIOST Author(s)
Lee, Hyi Seung(이희승)Lee, Yeon Ju(이연주)Shin, Hee Jae(신희재)
Alternative Author(s)
Mondol Md; 김지혜; 이희승; 이연주; 신희재
Publication Year
2011-06-15
Abstract
Bioactivity-guided isolation for the new/novel metabolites from the EtOAc extract obtained from the culture broth of a marine Bacillus sp. 09ID194 followed by chromatographic fractionations and subsequently HPLC purifications led to the isolation of two known macrolides, macrolactins A (1) and Q (2), together with a new glycosylated marcrolide, macrolactin W (3). The chemical structures of compounds 1-3 were assigned based on extensive MS and NMR spectral data analysis and literature review. Compound 3 showed potent antibacterial activity against both Gram-positive and Gram-negative pathogenic bacteria. (C) 2011 Published by Elsevier Ltd.
ISSN
0960-894X
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/3857
DOI
10.1016/j.bmcl.2010.12.050
Bibliographic Citation
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.21, no.12, pp.3832 - 3835, 2011
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Subject
BACTERIUM; LACTONES
Keywords
Macrolactins; MIC; NMR; Antibacterial activity; Macrolides
Type
Article
Language
English
Document Type
Article
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
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