Macrolactin W, a new antibacterial macrolide from a marine Bacillus sp.
SCIE
SCOPUS
Cited 42 time in
WEB OF SCIENCE
Cited 47 time in
Scopus
-
Title
- Macrolactin W, a new antibacterial macrolide from a marine Bacillus sp.
-
Author(s)
- Mondol, M. A. Mojid; Kim, Ji Hye; Lee, Hyi-Seung; Lee, Yeon-Ju; Shin, Hee Jae
- KIOST Author(s)
- Lee, Hyi Seung(이희승); Lee, Yeon Ju(이연주); Shin, Hee Jae(신희재)
-
Alternative Author(s)
- Mondol Md; 김지혜; 이희승; 이연주; 신희재
-
Publication Year
- 2011-06-15
-
Abstract
- Bioactivity-guided isolation for the new/novel metabolites from the EtOAc extract obtained from the culture broth of a marine Bacillus sp. 09ID194 followed by chromatographic fractionations and subsequently HPLC purifications led to the isolation of two known macrolides, macrolactins A (1) and Q (2), together with a new glycosylated marcrolide, macrolactin W (3). The chemical structures of compounds 1-3 were assigned based on extensive MS and NMR spectral data analysis and literature review. Compound 3 showed potent antibacterial activity against both Gram-positive and Gram-negative pathogenic bacteria. (C) 2011 Published by Elsevier Ltd.
-
ISSN
- 0960-894X
-
URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/3857
-
DOI
- 10.1016/j.bmcl.2010.12.050
-
Bibliographic Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.21, no.12, pp.3832 - 3835, 2011
-
Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
-
Subject
- BACTERIUM; LACTONES
-
Keywords
- Macrolactins; MIC; NMR; Antibacterial activity; Macrolides
-
Type
- Article
-
Language
- English
-
Document Type
- Article
- Files in This Item:
-
There are no files associated with this item.
Items in ScienceWatch@KIOST are protected by copyright, with all rights reserved, unless otherwise indicated.