Centrodinium punctatum (Dinophyceae) produces significant levels of saxitoxin and related analogs SCIE SCOPUS

Cited 8 time in WEB OF SCIENCE Cited 10 time in Scopus
Title
Centrodinium punctatum (Dinophyceae) produces significant levels of saxitoxin and related analogs
Author(s)
Shin, Hyeon Ho; Li, Zhun; Réveillon, Damien; Rovillon, Georges-Augustin; Mertens, Kenneth Neil; Hess, Philipp; Kim, Hyunjung; Lee, Jihoon; Lee, Kyun Woo; Kim, Daekyung; Park, Bum Soo; Hwang, Jinik; Seo, Min Ho; Lim, Weol Ae
KIOST Author(s)
Shin, Hyeon Ho(신현호)Lee, Ji Hoon(이지훈)Lee, Kyun Woo(이균우)
Publication Year
2020-12
Abstract
Centrodinium punctatum is a fusiform dinoflagellate with a global marine distribution. Due to a close phylogenetic relationship of one C. punctatum strain to Alexandrium species, toxin production of this C. punctatum strain was assessed using liquid chromatography coupled to tandem mass spectrometry. The paralytic shellfish toxin (PST) profile of C. punctatum was dominated by six analogs, i.e. STX (30%), GTX-1 (20%) and neoSTX (24%), followed by GTX-2 (9%), GTX-4 (9%) and GTX-3 (8%); deoxy-STX was also putatively identified while no gymnodimines, spirolides or goniodomins were detected. This is the first record of C. punctatum producing saxitoxins. The estimated cellular toxicity was rather elevated, between 91 and 212 pg cell(-1) (or 259 and 601 fmol cell(-1)). When considering the toxicity equivalent factors, results suggest that this species can produce high cellular toxicity compared to other STX-producing dinoflagellates. Morphological details of the sulcal area and the hypotheca of Centrodinium punctatum were re-examined by scanning electron microscopy (SEM); this revealed that in the sulcal area, the left posterior sulcal plate (Ssp) is larger and longer than the left posterior sulcal plate and extended into the hypotheca. Based on the morphological observation, a revised interpretation of the sulcus and hypotheca is proposed.
ISSN
1568-9883
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/38556
DOI
10.1016/j.hal.2020.101923
Bibliographic Citation
HARMFUL ALGAE, v.100, 2020
Publisher
ELSEVIER
Subject
PARALYTIC SHELLFISH TOXINS; GENUS ALEXANDRIUM; PHYLOGENY; BIOSYNTHESIS; BIOGEOGRAPHY; TEMPERATURE; VARIABILITY; MORPHOLOGY; TOXICITY; STRAINS
Keywords
Dinoflagellate; Alexandrium; PST; STX; neoSTX; Gonyautoxin
Type
Article
Language
English
Document Type
Article
Publisher
ELSEVIER
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