Polyopes affinis alleviates airway inflammation in a murine model of allergic asthma SCIE SCOPUS

Cited 16 time in WEB OF SCIENCE Cited 19 time in Scopus
Title
Polyopes affinis alleviates airway inflammation in a murine model of allergic asthma
Author(s)
Lee, Dae-Sung; Park, Won Sun; Heo, Soo-Jin; Cha, Seon-Heui; Kirn, Daekyung; Jeon, You-Jin; Park, Sae-Gwang; Seo, Su-Kil; Choi, Jung Sik; Park, Sung-Jae; Shim, Eun Bo; Choi, Il-Whan; Jung, Won-Kyo
KIOST Author(s)
Heo, Soo Jin(허수진)
Alternative Author(s)
허수진
Publication Year
2011-12
Abstract
Marine algae have been utilized in food as well as medicine products for a variety of purposes. The purpose of this study was to determine whether an ethanol extract of Polyopes affinis (P. affinis) can inhibit the pathogenesis of T helper 2 (Th2)-mediated allergen-induced airway inflammation in a murine model of asthma. Mice that were sensitized and challenged with ovalbumin (OVA) evidenced typical asthmatic reactions such as the following: an increase in the number of eosinophils in the bronchoalveolar lavage (BAL) fluid; a marked influx of inflammatory cells into the lung around blood vessels and airways as well as the narrowing of the airway luminal; the development of airway hyperresponsiveness (AHR); the presence of pulmonary Th2 cytokines; and the presence of allergen-specific immunoglobulin E (IgE) in the serum. The successive intraperitoneal administration of P. affinis ethanolic extracts before the last airway OVA-challenge resulted in a significant inhibition of all asthmatic reactions. These data suggest that P. affinis ethanolic extracts possess therapeutic potential for the treatment of pulmonary allergic disorders such as allergic asthma.
ISSN
0250-5991
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/3788
DOI
10.1007/s12038-011-9152-8
Bibliographic Citation
JOURNAL OF BIOSCIENCES, v.36, no.5, pp.869 - 877, 2011
Publisher
INDIAN ACAD SCIENCES
Subject
T-CELLS; RED ALGA; EOSINOPHILS; DISEASE; RESPONSIVENESS; PATHOGENESIS; FUCOXANTHIN; EXPRESSION; IGE
Keywords
Asthma; free radical; IgE; phlorotannins; Polyopes affinis
Type
Article
Language
English
Document Type
Article
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