Polyopes affinis alleviates airway inflammation in a murine model of allergic asthma
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Title
- Polyopes affinis alleviates airway inflammation in a murine model of allergic asthma
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Author(s)
- Lee, Dae-Sung; Park, Won Sun; Heo, Soo-Jin; Cha, Seon-Heui; Kirn, Daekyung; Jeon, You-Jin; Park, Sae-Gwang; Seo, Su-Kil; Choi, Jung Sik; Park, Sung-Jae; Shim, Eun Bo; Choi, Il-Whan; Jung, Won-Kyo
- KIOST Author(s)
- Heo, Soo Jin(허수진)
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Alternative Author(s)
- 허수진
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Publication Year
- 2011-12
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Abstract
- Marine algae have been utilized in food as well as medicine products for a variety of purposes. The purpose of this study was to determine whether an ethanol extract of Polyopes affinis (P. affinis) can inhibit the pathogenesis of T helper 2 (Th2)-mediated allergen-induced airway inflammation in a murine model of asthma. Mice that were sensitized and challenged with ovalbumin (OVA) evidenced typical asthmatic reactions such as the following: an increase in the number of eosinophils in the bronchoalveolar lavage (BAL) fluid; a marked influx of inflammatory cells into the lung around blood vessels and airways as well as the narrowing of the airway luminal; the development of airway hyperresponsiveness (AHR); the presence of pulmonary Th2 cytokines; and the presence of allergen-specific immunoglobulin E (IgE) in the serum. The successive intraperitoneal administration of P. affinis ethanolic extracts before the last airway OVA-challenge resulted in a significant inhibition of all asthmatic reactions. These data suggest that P. affinis ethanolic extracts possess therapeutic potential for the treatment of pulmonary allergic disorders such as allergic asthma.
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ISSN
- 0250-5991
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/3788
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DOI
- 10.1007/s12038-011-9152-8
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Bibliographic Citation
- JOURNAL OF BIOSCIENCES, v.36, no.5, pp.869 - 877, 2011
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Publisher
- INDIAN ACAD SCIENCES
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Subject
- T-CELLS; RED ALGA; EOSINOPHILS; DISEASE; RESPONSIVENESS; PATHOGENESIS; FUCOXANTHIN; EXPRESSION; IGE
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Keywords
- Asthma; free radical; IgE; phlorotannins; Polyopes affinis
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Type
- Article
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Language
- English
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Document Type
- Article
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