Evaluation of antioxidant properties of a new compound, pyrogallol-phloroglucinol-6,6 '-bieckol isolated from brown algae, Ecklonia cava
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Title
- Evaluation of antioxidant properties of a new compound, pyrogallol-phloroglucinol-6,6 '-bieckol isolated from brown algae, Ecklonia cava
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Author(s)
- Kang, Sung-Myung; Lee, Seung-Hong; Heo, Soo-Jin; Kim, Kil-Nam; Jeon, You-Jin
- KIOST Author(s)
- Heo, Soo Jin(허수진)
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Alternative Author(s)
- 허수진
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Publication Year
- 2011-12
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Abstract
- In this study, antioxidant and free radical scavenging activities of the natural antioxidative compound, pyrogallol-phloroglucinol-6,6'-bieckol (PPB) isolated from brown algae, Ecklonia cova was assessed in vitro by measuring the radical scavenging activities (DPPH, alkyl, hydroxyl, and superoxide) using electron spin resonance (ESR) spectrometry, intracellular reactive oxygen species (ROS) scavenging activity, and DNA damage assay. According to the results of these experiments, the scavenging activity PPB against difference radicals was in the following order: DPPH, alkyl, hydroxyl, and superoxide radicals (IC50; 0.90, 2.54, 62.93 and 109.05 mu M). The antioxidant activities of PPB were higher than that of the commercial antioxidant, ascorbic acid. Furthermore, PPB effectively inhibited DNA damage induced by H2O2. These results suggest that the natural antioxidative compound. PPB, can be used by the natural food industry.
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ISSN
- 1976-1457
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/3784
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DOI
- 10.4162/nrp.2011.5.6.495
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Bibliographic Citation
- NUTRITION RESEARCH AND PRACTICE, v.5, no.6, pp.495 - 502, 2011
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Publisher
- KOREAN NUTRITION SOC
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Subject
- RADICAL-SCAVENGING CAPACITY; MEDICINAL-PLANTS; TEA CATECHINS; FLAVONOIDS; DAMAGE; ASSAY; ESR
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Keywords
- Ecklonia cava; brown algae; pyrogallol-phloroglueinol-6,6 ' -bieckol; antioxidant
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Type
- Article
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Language
- English
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Document Type
- Article
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