Ieodoglucomides A and B from a Marine-Derived Bacterium Bacillus licheniformis SCIE SCOPUS

Cited 37 time in WEB OF SCIENCE Cited 39 time in Scopus
Title
Ieodoglucomides A and B from a Marine-Derived Bacterium Bacillus licheniformis
Author(s)
Tareq, Fakir Shahidullah; Kim, Ji Hye; Lee, Min Ah; Lee, Hyi-Seung; Lee, Yeon-Ju; Lee, Jong Seok; Shin, Hee Jae
KIOST Author(s)
Lee, Min Ah(이민아)Lee, Hyi Seung(이희승)Lee, Yeon Ju(이연주)Lee, Jong Seok(이종석)Shin, Hee Jae(신희재)
Alternative Author(s)
TAREQ; 김지혜; 이민아; 이희승; 이연주; 이종석; 신희재
Publication Year
2012-03-16
Abstract
Ieodoglucomides A (1) and B (2), unique glycolipopeptides consisting of an amino acid, a new fatty acid, a succinic acid, and a sugar, were isolated from a Marine-derived bacterium Bacillus licheniformis. The absolute stereochemistry of 1 and 2 was determined by deploying coupling constants, Marfey's and Mosher's methods, and literature reviews. Compounds 1 and 2 displayed moderate in vitro antimicrobial activity. Furthermore, ieodoglucomide B (2) exhibited cytotoxic activity against lung cancer and stomach cancer cell lines with GI(50) values of 25.18 and 17.78 mu g/mL, respectively.
ISSN
1523-7060
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/3609
DOI
10.1021/ol300202z
Bibliographic Citation
ORGANIC LETTERS, v.14, no.6, pp.1464 - 1467, 2012
Publisher
AMER CHEMICAL SOC
Subject
ANTIBACTERIAL; CEREBROSIDES; GLYCOLIPIDS
Type
Article
Language
English
Document Type
Article
Publisher
AMER CHEMICAL SOC
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