Ieodoglucomides A and B from a Marine-Derived Bacterium Bacillus licheniformis SCIE SCOPUS
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- Title
- Ieodoglucomides A and B from a Marine-Derived Bacterium Bacillus licheniformis
- KIOST Author(s)
- Lee, Min Ah(이민아); Lee, Hyi Seung(이희승); Lee, Yeon Ju(이연주); Lee, Jong Seok(이종석); Shin, Hee Jae(신희재)
- Alternative Author(s)
- TAREQ; 김지혜; 이민아; 이희승; 이연주; 이종석; 신희재
- Publication Year
- 2012-03-16
- Abstract
- Ieodoglucomides A (1) and B (2), unique glycolipopeptides consisting of an amino acid, a new fatty acid, a succinic acid, and a sugar, were isolated from a Marine-derived bacterium Bacillus licheniformis. The absolute stereochemistry of 1 and 2 was determined by deploying coupling constants, Marfey's and Mosher's methods, and literature reviews. Compounds 1 and 2 displayed moderate in vitro antimicrobial activity. Furthermore, ieodoglucomide B (2) exhibited cytotoxic activity against lung cancer and stomach cancer cell lines with GI(50) values of 25.18 and 17.78 mu g/mL, respectively.
- ISSN
- 1523-7060
- Bibliographic Citation
- ORGANIC LETTERS, v.14, no.6, pp.1464 - 1467, 2012
- Publisher
- AMER CHEMICAL SOC
- Subject
- ANTIBACTERIAL; CEREBROSIDES; GLYCOLIPIDS
- Type
- Article
- Language
- English
- Document Type
- Article
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- There are no files associated with this item.
