Nortriterpene Glycosides of the Sarasinoside Class from the Sponge Lipastrotethya sp.
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Title
- Nortriterpene Glycosides of the Sarasinoside Class from the Sponge Lipastrotethya sp.
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Author(s)
- Lee, Jung-Ho; Jeon, Ju-eun; Lee, Yeon-Ju; Lee, Hyi-Seung; Sim, Chung J.; Oh, Ki-Bong; Shin, Jongheon
- KIOST Author(s)
- Lee, Yeon Ju(이연주); Lee, Hyi Seung(이희승)
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Alternative Author(s)
- 이연주; 이희승
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Publication Year
- 2012-07
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Abstract
- Five new nortriterpene glycosides, along with eight known compounds of the sarasinoside class, were isolated from the tropical sponge Lipastrotethya sp. collected from Chuuk, Micronesia. The structures of these new compounds, designated as sarasinosides N-R (9-13), were determined by combined spectroscopic and chemical methods. The aglycone portions of 10-13 were found to be unprecedented among nortriterpeneoids on the basis of extensive NMR analyses. Several of these compounds exhibited cytotoxicity against A549 and K562 cell lines as well as weak inhibitory activity. against Na+/K+-ATPase.
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ISSN
- 0163-3864
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/3494
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DOI
- 10.1021/np300297d
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Bibliographic Citation
- JOURNAL OF NATURAL PRODUCTS, v.75, no.7, pp.1365 - 1372, 2012
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Publisher
- AMER CHEMICAL SOC
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Subject
- MARINE NATURAL-PRODUCTS; ASTEROPUS-SARASINOSUM; TRITERPENOID SAPONINS; OLIGOGLYCOSIDES; GALACTOSIDES; GROWTH; ASSAY; C1; B1; A1
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Type
- Article
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Language
- English
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Document Type
- Article
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