Monanchomycalins A and B, unusual guanidine alkaloids from the sponge Monanchora pulchra
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Title
- Monanchomycalins A and B, unusual guanidine alkaloids from the sponge Monanchora pulchra
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Author(s)
- Makarieva, Tatyana N.; Tabakmaher, Ksenya M.; Guzii, Alla G.; Denisenko, Vladimir A.; Dmitrenok, Pavel S.; Kuzmich, Alexandra S.; Lee, Hyi-Seung; Stonik, Valentin A.
- KIOST Author(s)
- Lee, Hyi Seung(이희승)
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Alternative Author(s)
- 이희승
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Publication Year
- 2012-08-08
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Abstract
- New pentacyclic guanidine alkaloids, monanchomycalins A (1) and B (2) were isolated from the marine sponge, Monanchora pulchra and their structures elucidated using NMR, HRMALDI-TOF-MS, and HRESI MS, as well as by chemical transformations of 1. Compounds 1 and 2 exhibited potent cytotoxic activities against HL-60 human leukemia cells with IC50 values of 120 and 140 nM, respectively. (C) 2012 Elsevier Ltd. All rights reserved.
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ISSN
- 0040-4039
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/3475
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DOI
- 10.1016/j.tetlet.2012.05.162
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Bibliographic Citation
- TETRAHEDRON LETTERS, v.53, no.32, pp.4228 - 4231, 2012
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Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
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Subject
- PTILOMYCALIN-A; CRAMBE-CRAMBE; CRAMBESCIDIN-800; HIV-1
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Keywords
- Pentacyclic guanidine alkaloids; Monanchomycalins; Spermidine; Marine sponge; Monanchora pulchra
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Type
- Article
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Language
- English
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Document Type
- Article
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