Ascorbic acid alleviates toxicity of paclitaxel without interfering with the anticancer efficacy in mice SCIE SCOPUS

Cited 18 time in WEB OF SCIENCE Cited 22 time in Scopus
Title
Ascorbic acid alleviates toxicity of paclitaxel without interfering with the anticancer efficacy in mice
Author(s)
Park, Jin-Hee; Davis, Keith R.; Lee, Gunsup; Jung, Manyong; Jung, Yuchul; Park, Jungan; Yi, Sang-Yeop; Lee, Myung-Ah; Lee, Sukchan; Yeom, Chang-Hwan; Kim, Jin
Publication Year
2012-11
Abstract
Paclitaxel is used extensively as a chemotherapeutic agent against a broad range of tumors but often leads to the early termination of treatment due to severe toxic side effects. In this study, we hypothesized that ascorbic acid could reduce the toxic side effects without interfering with the anticancer effect of paclitaxel. To demonstrate this, we examined the effect of the combinational treatment of ascorbic acid and paclitaxel using H1299 (a non-small cell lung cancer cell line) and BALB/c mice implanted with or without sarcoma 180 cancer cells. In H1299 cells, the anticancer effects of the combinational treatment with paclitaxel and ascorbic acid were up to 1.7-foldhigher than those of single-agent paclitaxel treatment. In addition, it was shown that the viability of the HEL299 normal cells was up to 1.6-fold higher with the combinational treatment than with paclitaxel treatment alone. In vivo mouse experiments also showed that mice co-treated with paclitaxel and ascorbic acid did not exhibit the typical side effects induced by paclitaxel, such as a reduction in the numbers of white blood cells and red blood cells and the level of hemoglobin (P < .05). The analysis of cancer-related gene expression by quantitative real-time polymerase chain reaction and immunohistochemistry revealed that the combinational treatment suppressed cancer cell multiplication. Taken together, these results suggest that combinational chemotherapy with ascorbic acid and paclitaxel not only does not block the anticancer effects of paclitaxel but also alleviates the cytotoxicity of paclitaxel in vivo and in vitro. (c) 2012 Elsevier Inc. All rights reserved.
ISSN
0271-5317
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/3432
DOI
10.1016/j.nutres.2012.09.011
Bibliographic Citation
NUTRITION RESEARCH, v.32, no.11, pp.873 - 883, 2012
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Subject
CELL LUNG-CANCER; VITAMIN-C; IN-VITRO; CHEMOTHERAPY; GROWTH; CARCINOMA; CISPLATIN; INHIBITION; PROOXIDANT
Keywords
Alleviatory effect; Ascorbic acid; Paclitaxel; Combinational treatment; Cytotoxicity
Type
Article
Language
English
Document Type
Article
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Files in This Item:
There are no files associated with this item.

qrcode

Items in ScienceWatch@KIOST are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse