GLYCOSYLATED METHOXY-MACROLACTINS FROM A MARINE SEDIMENT BACTERIUM BACILLUS SUBTILIS SCIE SCOPUS

Cited 3 time in WEB OF SCIENCE Cited 3 time in Scopus
Title
GLYCOSYLATED METHOXY-MACROLACTINS FROM A MARINE SEDIMENT BACTERIUM BACILLUS SUBTILIS
Author(s)
Shin, Hee Jae; Tareq, Fakir Shahidullah; Kim, Ji Hye; Lee, Min Ah; Lee, Hyi-Seung; Lee, Yeon-Ju; Lee, Jong-Seok
KIOST Author(s)
Shin, Hee Jae(신희재)Lee, Min Ah(이민아)Lee, Hyi Seung(이희승)Lee, Yeon Ju(이연주)Lee, Jong Seok(이종석)
Alternative Author(s)
신희재; TAREQ; 김지혜; 이민아; 이희승; 이연주; 이종석
Publication Year
2013-02-01
Abstract
Fermentation of a bacterium Bacillus subtilis isolated from the marine sediment sample collected at Gageocho, Republic of Korea in sea water based modified Bennett's medium followed by double ethyl acetate (EA) extraction of the supernatant, sequential fractionations and purifications afforded three new glycosylated methoxy-macrolactins (1-3). The characterization of these compounds was achieved by various spectroscopic techniques including HRESIMS and extensive 1D and 2D NMR data analyses. The stereoconfiguration was assigned based on the chemical derivatization studies and literature data reviews. Methoxy macrolactins were found to exhibit good antimicrobial properties when tested against bacteria and fungi. But, these compounds did not display any antiplasmodial activity against Plasmodium falciparum (D10).
ISSN
0385-5414
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/3266
DOI
10.3987/COM-12-12594
Bibliographic Citation
HETEROCYCLES, v.87, no.2, pp.307 - 318, 2013
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Subject
ANTIBACTERIAL; DEEP
Keywords
Macrolactin; Marine Bacterium; Antimicrobial; Antifungal; Macrolide
Type
Article
Language
English
Document Type
Article
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
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