GLYCOSYLATED METHOXY-MACROLACTINS FROM A MARINE SEDIMENT BACTERIUM BACILLUS SUBTILIS
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Title
- GLYCOSYLATED METHOXY-MACROLACTINS FROM A MARINE SEDIMENT BACTERIUM BACILLUS SUBTILIS
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Author(s)
- Shin, Hee Jae; Tareq, Fakir Shahidullah; Kim, Ji Hye; Lee, Min Ah; Lee, Hyi-Seung; Lee, Yeon-Ju; Lee, Jong-Seok
- KIOST Author(s)
- Shin, Hee Jae(신희재); Lee, Min Ah(이민아); Lee, Hyi Seung(이희승); Lee, Yeon Ju(이연주); Lee, Jong Seok(이종석)
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Alternative Author(s)
- 신희재; TAREQ; 김지혜; 이민아; 이희승; 이연주; 이종석
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Publication Year
- 2013-02-01
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Abstract
- Fermentation of a bacterium Bacillus subtilis isolated from the marine sediment sample collected at Gageocho, Republic of Korea in sea water based modified Bennett's medium followed by double ethyl acetate (EA) extraction of the supernatant, sequential fractionations and purifications afforded three new glycosylated methoxy-macrolactins (1-3). The characterization of these compounds was achieved by various spectroscopic techniques including HRESIMS and extensive 1D and 2D NMR data analyses. The stereoconfiguration was assigned based on the chemical derivatization studies and literature data reviews. Methoxy macrolactins were found to exhibit good antimicrobial properties when tested against bacteria and fungi. But, these compounds did not display any antiplasmodial activity against Plasmodium falciparum (D10).
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ISSN
- 0385-5414
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/3266
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DOI
- 10.3987/COM-12-12594
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Bibliographic Citation
- HETEROCYCLES, v.87, no.2, pp.307 - 318, 2013
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Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
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Subject
- ANTIBACTERIAL; DEEP
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Keywords
- Macrolactin; Marine Bacterium; Antimicrobial; Antifungal; Macrolide
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Type
- Article
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Language
- English
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Document Type
- Article
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