Anti-inflammatory effects of trans-1,3-diphenyl-2,3-epoxypropane-1-one mediated by suppression of inflammatory mediators in LPS-stimulated RAW 264.7 macrophages SCIE SCOPUS

Cited 35 time in WEB OF SCIENCE Cited 38 time in Scopus
Title
Anti-inflammatory effects of trans-1,3-diphenyl-2,3-epoxypropane-1-one mediated by suppression of inflammatory mediators in LPS-stimulated RAW 264.7 macrophages
Author(s)
Kim, Kil-Nam; Ko, Yeong-Jong; Kang, Min-Cheol; Yang, Hye-Mi; Roh, Seong Woon; Oda, Tatsuya; Jeon, You-Jin; Jung, Won-Kyo; Heo, Soo-Jin; Yoon, Weon-Jong; Kim, Daekyung
KIOST Author(s)
Heo, Soo Jin(허수진)
Publication Year
2013-03
Abstract
To assess the potential therapeutic properties of trans-1,3-diphenyl-2,3-epoxypropane-1-one (DPEP), its anti-inflammatory effects were investigated in lipopolysaccharide (LPS)-stimulated mouse macrophage (RAW 264.7) cells. DPEP induced dose-dependent reduction of the protein levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) and concomitant reduction in the production of NO and prostaglandin E-2 (PGE(2)). Additionally, DPEP suppressed the production of inflammatory cytokines, including tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1 beta, and IL-6. We investigated the mechanism by which DPEP inhibits NO and PGE(2) by examining the level of nuclear factor-kappa B (NF-kappa B) activation within the mitogen-activated protein kinase (MAPK) pathway, which is an inflammation-induced signaling pathway in RAW 264.7 cells. DPEP inhibited LPS-induced phosphorylation of ERK, JNK, and p38. Furthermore, DPEP inhibited the LPS-induced phosphorylation of inhibitor kappa B (I kappa B)-alpha and NF-kappa B p50. Taken together, the results of this study demonstrate that DPEP inhibits LPS-stimulated inflammation by blocking the NF-kappa B and MAPK pathways in macrophages. (c) 2012 Elsevier Ltd. All rights reserved.
ISSN
0278-6915
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/3215
DOI
10.1016/j.fct.2012.12.021
Bibliographic Citation
FOOD AND CHEMICAL TOXICOLOGY, v.53, pp.371 - 375, 2013
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Subject
NITRIC-OXIDE SYNTHASE; NF-KAPPA-B; NECROSIS-FACTOR-ALPHA; SIGNAL-REGULATED KINASE; BIOLOGICAL EVALUATION; MURINE MACROPHAGES; GENE-EXPRESSION; DOWN-REGULATION; INHIBITION; PATHWAYS
Keywords
Trans-1,3-diphenyl-2,3-epoxypropan-1-one (DPEP); Anti-inflammatory; Macrophage; NF-kappa B; MAPKs
Type
Article
Language
English
Document Type
Article
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Related Researcher
Research Interests

Marine Biotechnology,Marine Natural Products,Bioactivities,해양생물공학,해양천연물학,생리활성

Files in This Item:
There are no files associated with this item.

qrcode

Items in ScienceWatch@KIOST are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse