OCPs에 의한 바지락 패주의 AChe 활동도 저해

Abstract

A range of exposure concentrations were selected to establish the relationship between the AChE activity in Manila clams (Ruditapes philippinarum) and organophosphorous pesticides. The experiment showed a dose-response relationship for AChE inhibition in the adductor muscle of Manila clam over wide concentration ranges of organophosphorous pesticides (chlorpyrifos, methidathion, IBP, diazinon). Extent of AChE activity reduction depends on exposure duration to chlorpyrifos in an experiment with clams exposed to 0.3 mg/L chlorpyrifos for 48 h. The optimum pH of homogeneizing buffer for AChE activity in the adductor muscle was found to be 8.0. Among different tissues of Manila clams AChE inhibition was the highest in the adductor muscle followed by gill. It is suggested that that the inhibition of AChE activity in the adductor muscle of Manila clams could be used as a monitoring tool for the bioeffects caused by these contaminants.