Genomic expression responses toward bisphenol-A toxicity in Daphnia magna in terms of reproductive activity SCIE SCOPUS KCI

Cited 30 time in WEB OF SCIENCE Cited 33 time in Scopus
Title
Genomic expression responses toward bisphenol-A toxicity in Daphnia magna in terms of reproductive activity
Author(s)
Jeong, Seok Won; Lee, Sang Min; Yum, Seung Shic; Iguchi, Taisen; Seo, Young Rok
KIOST Author(s)
Yum, Seung Shic(염승식)
Publication Year
2013-06
Abstract
Bisphenol-A (BPA) classified as an endocrine disruptor that can interfere endocrine system, leading to adverse developmental, reproductive, neurological, and immunological effects in both humans and wildlife. To study the reproductive and geno-toxicological effects of BPA in aquatic ecosystem, we employed Daphnia magna (D. magna) as a test animal model. D. magna in one of the most widely used water species employed in ecotoxicology testing all over the world. As a result, the reproductive activity based on the number of offspring production is significantly reduced toward 21 day exposure to 10 mg/L of BPA, compared with control. Gene expression profiles in response to BPA exposure using DNA microarray analysis was subsequently carried out. Our data showed that expression levels of numerous putative genes with nucleotide sequences homology to animal models including cuticular protein, vitellogenin, protease, ribosomal protein family were altered. These genes which are critically reported in other animal systems could be considered as novel biomarkers in response to BPA exposure.
ISSN
1738-642X
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/3161
DOI
10.1007/s13273-013-0019-y
Bibliographic Citation
MOLECULAR & CELLULAR TOXICOLOGY, v.9, no.2, pp.149 - 158, 2013
Publisher
KOREAN SOCIETY TOXICOGENOMICS & TOXICOPROTEOMICS-KSTT
Keywords
Bisphenol-A; Daphnia magna; Reproduction test; Microarray; Biomarker
Type
Article
Language
English
Document Type
Article
Publisher
KOREAN SOCIETY TOXICOGENOMICS & TOXICOPROTEOMICS-KSTT
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