Changes in gene expression profile due to acute toxicity of toxaphene in the marine medaka
SCIE
SCOPUS
KCI
Cited 4 time in
WEB OF SCIENCE
Cited 6 time in
Scopus
-
Title
- Changes in gene expression profile due to acute toxicity of toxaphene in the marine medaka
-
Author(s)
- Lee, Aekyung; Woo, Seonock; Won, Hyokyoung; Lee, Gunsup; Lee, Taek-Kyun; Yum, Seungshic
- KIOST Author(s)
- Woo, Seon Ock(우선옥); Lee, Taek Kyun(이택견); Yum, Seung Shic(염승식)
-
Alternative Author(s)
- 우선옥; 원효경; 이건섭; 이택견; 염승식
-
Publication Year
- 2013-06
-
Abstract
- Differential gene expression profiling was performed using cDNA microarray hybridization on the hepatic tissue of the marine medaka (Oryzias javanicus) after exposure to toxaphene, which is classified as a persistent organic pollutant. Ninety-seven differentially expressed candidate genes were identified; 40 were induced and 57 were repressed (P < 0.05). The genes were assembled into 18 groups based mainly on the Eukaryotic Orthologous Groups classification. These isolated gene candidates were differentially expressed and therefore have great potential as molecular biomarkers for identifying environmental stressors and prognosis for the biological effects of the toxicant. Some of the genes were closely related to endocrine disruption, renal and cardiovascular disease, tumorigenesis, immune responses, and detoxification. Our results will allow future studies to assess the molecular mechanisms of toxaphene toxicity and to develop a systems biology approach to environmental stress biology.
-
ISSN
- 1738-642X
-
URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/3160
-
DOI
- 10.1007/s13273-013-0016-1
-
Bibliographic Citation
- MOLECULAR & CELLULAR TOXICOLOGY, v.9, no.2, pp.121 - 128, 2013
-
Publisher
- KOREAN SOCIETY TOXICOGENOMICS & TOXICOPROTEOMICS-KSTT
-
Keywords
- Toxaphene; Marine medaka; Differential gene expression profile; cDNA microarray
-
Type
- Article
-
Language
- English
-
Document Type
- Article
- Files in This Item:
-
There are no files associated with this item.
Items in ScienceWatch@KIOST are protected by copyright, with all rights reserved, unless otherwise indicated.