해양방선균에서 분리된 신규 항암물질

Title
해양방선균에서 분리된 신규 항암물질
Alternative Title
New Anticancer Compounds from Marine Actinomycetes
Author(s)
신희재; 김태식; 정성윤; 이희승
KIOST Author(s)
Shin, Hee Jae(신희재)Lee, Hyi Seung(이희승)
Alternative Author(s)
신희재; 김태식; 정성윤; 이희승
Publication Year
2005-06-11
Abstract
Actinomycetes are a well-proven source of diverse secondary metabolites having broad ranges of biological activities such as antibiotic, anticancer and immunosuppressant. However, marine actinomycetes have been largely ignored until recently. As part of a continuing program to develop the biomedical potential of marine microorganisms, we have focused considerable attention on the marine actinomycetes. From the marine samples such as deep sea and shallow water sediments, plants and invertebrates, more than 4,000 strains of marine derived actinomycetes were isolated. We have established that about 10% of isolates show some bioactivity in our assays such as cytotoxicity, antifungal, antimicrobial, and enzyme inhibitory activities. From the bioactive isolates several new actinomycetes have been identified and a variety of bioactive molecules were characterized. We present here the discovery of anticancer compounds from actinomycetes. The isolation, structure determination, and biological activity of new compounds from marine actinomycetes will be presented.
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/31425
Bibliographic Citation
International Marine Biotechnology Conference, pp.289, 2005
Publisher
International Marine Biotechnology Association
Type
Conference
Language
English
Publisher
International Marine Biotechnology Association
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