Identification of bioactive metabolites against adenosine A1 receptor using NMR-based metabolomics SCIE SCOPUS

Cited 13 time in WEB OF SCIENCE Cited 14 time in Scopus
Title
Identification of bioactive metabolites against adenosine A1 receptor using NMR-based metabolomics
Author(s)
Ali, Kashif; Iqbal, Muzamal; Yuliana, Nancy Dewi; Lee, Yeon-Ju; Park, Seungil; Han, Saem; Lee, Jeong-Woo; Lee, Hyi-Seung; Verpoorte, Robert; Choi, Young Hae
KIOST Author(s)
Lee, Yeon Ju(이연주)Lee, Hyi Seung(이희승)
Publication Year
2013-08
Abstract
Marine sponges are relatively less explored for their chemical features but highly anticipated resource for bioactive compounds. In this paper we report the screening of marine sponges crude extracts for their potential to bind the adenosine A1 receptor. Many samples showed very promising activity and in order to identify the active components, a metabolomics-chemometrics approach is employed. Nuclear magnetic resonance spectroscopy is used for the metabolic profiling of the marine sponges and partial least squares (PLS) and orthogonal PLS (OPLS) algorithms are used to correlate the metabolomics with bioactivity data. Using several two dimensional-NMR techniques, the resonances responsible for the separation of high activity samples from the medium and low activity samples were identified as associated to metabolites like halisulfate 1, halisulfate 3-5, and suvanine (1-5), all belongs to sesterterpenes class. The reference compounds for these metabolites are also tested for the activity, which endorse the findings of the applied methodology.
ISSN
1573-3882
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/3141
DOI
10.1007/s11306-013-0498-9
Bibliographic Citation
METABOLOMICS, v.9, no.4, pp.778 - 785, 2013
Publisher
SPRINGER
Subject
SESTERTERPENE SULFATE; ADIPOSE-TISSUE; SPONGE; BINDING; PLANTS
Keywords
Marine sponges; Halisulfates; Suvanine; Adenosine A1 receptor binding; NMR spectroscopy; Chemometrics
Type
Article
Language
English
Document Type
Article
Publisher
SPRINGER
Related Researcher
Research Interests

Marine Natural Products,Organic Chemistry,해양천연물,유기화학

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