Seafood comprising fish and invertebrates has been a substantial supplier of protein and other nutrients to Korean diet traditionally. Recent developmental activities in Korea has placed most of the coastal and nearby marine zone under considerable anthropogenic pollution leading to contamination of their seafood. An extensive, congener-specific analysis of polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzo-furans (PCDFs) was conducted in Korean sea food. The random basket survey involved 17 species of fish, 9 species of invertebrates and five different processed food that are consumed by Koreans on a day to day basis. 46 PCDDs and PCDFs, including the toxic ones with international toxicity equivalent factors (TEFs) and 50 individual PCB congeners including potentially toxic mono- and non-ortho Cl substituted congeners (dioxin like PCBs) were measured using high resolution gas chromatography and mass spectrometry (HRGC-HRMS). The lipid normalized concentrations of these compounds were not alarming. The maximum dioxin (sum of detectable residues) concentration of 38.53 pg/g was recorded in ascidians and the maximum furan concentration of 9.23 pg/g was recorded in fish (herring). Among the 17 toxic PCDD/DFs in fish and invertebrates only 4 congeners were measured at <1.0 pg/g levels; in processed food only 7 congeners were measured at <0.9 pg/g levels. The sum of 50 PCB congeners in seafood ranged from 51 – 38191 pg/g lipid weight, in the following order fish>processed food>invertebrates. The survey clearly indicated that the present concentration levels of PCBs, dioxins and dibenzofurans in Korean diet is relatively low in comparison to other studies conducted elsewhere in the world. However, detailed congener-specific structure metabolic activity relationship analysis in these items showed possible induction of cytochrome P450 1A1 and IIB isozymes in fish and invertebrates. This metabolic stress is transfe