해양유래 미생물 스트렙토마이세스에서 분리된 노카다민류의 환상 펩타이드의 구조결정

Abstract

Actinomycetes have been the most significant source for compounds with biological activity and clinical usefulness. In an effort to search for novel marine natural products, we have collected more than 3,000 strains of actinomycetes from marine invertebrates, plants, and sediments. Herein we report the results of our chemical investigation on the biologically active metabolites from marine actinomycetes and structure determination based on comprehensive spectroscopic analysis. Bioactive clclic peptides of the nocardamine class were isolated from strains of actinomycetes and highly purified for NMR studies. Complete 1H, 13C-NMR signal assignments were made by using various homonuclear and heteronuclear 2D-NMR techniques. The Structure of compounds 1-3 were also determined by utilizing NOE observation and molecular dynamic computations.