해양유래 미생물 스트렙토마이세스에서 분리된 노카다민류의 환상 펩타이드의 구조결정

Title
해양유래 미생물 스트렙토마이세스에서 분리된 노카다민류의 환상 펩타이드의 구조결정
Alternative Title
Structure determination of Cyclic Peptides of the Nocardamine class from a marine-derived bacterium of the genus Streptomyces
Author(s)
김태식; 원호식; 신희재
Publication Year
2005-11-08
Abstract
Actinomycetes have been the most significant source for compounds with biological activity and clinical usefulness. In an effort to search for novel marine natural products, we have collected more than 3,000 strains of actinomycetes from marine invertebrates, plants, and sediments. Herein we report the results of our chemical investigation on the biologically active metabolites from marine actinomycetes and structure determination based on comprehensive spectroscopic analysis. Bioactive clclic peptides of the nocardamine class were isolated from strains of actinomycetes and highly purified for NMR studies. Complete 1H, 13C-NMR signal assignments were made by using various homonuclear and heteronuclear 2D-NMR techniques. The Structure of compounds 1-3 were also determined by utilizing NOE observation and molecular dynamic computations.
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/31194
Bibliographic Citation
The 44 Annual NMR Meeting of the NMR Society of Japan and The 1st Asia-Pacific NMR Symposium, pp.78, 2005
Publisher
The NMR Society of Japan
Type
Conference
Language
English
Publisher
The NMR Society of Japan
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