심해퇴적토 유래의 해양방선균으로부터 분리된 신규 항암물질

Abstract

A new cytotoxic compound and four known compounds, nonactic acid, dilactone, trilactone, and nonactin, were isloated from the fermentation broth of a marine actinomycete strain collected in deep-sea sediments. This strain was identified as Streptomyces sp. by biochemical tests and 16S rDNA analysis. This actinomyceted produces various bioactive secondary metabolites. Fractionations by solvent partitioning, silica vacuum flash chromatography, and reversed-phase HPLC gave a pure cytotoxic compound. Its structure was elucidated by FAB-MS, 1H, 13C, and 2D NMR spectroscopy. This compound exhibited sigificant cytotoxicity against seven human cancer cell lines but showed no growth inhibition against various microorganisms including bacteria, fungi, and yeast.