심해퇴적토 유래의 해양방선균으로부터 분리된 신규 항암물질

Title
심해퇴적토 유래의 해양방선균으로부터 분리된 신규 항암물질
Alternative Title
A new cytotoxic compound from a marine-derived Streptomyces sp. isolated from deep-sea sediment
Author(s)
신희재; 정성윤; 김태식; 정현선; 이희승
KIOST Author(s)
Lee, Hyi Seung(이희승)
Publication Year
2006-04-16
Abstract
A new cytotoxic compound and four known compounds, nonactic acid, dilactone, trilactone, and nonactin, were isloated from the fermentation broth of a marine actinomycete strain collected in deep-sea sediments. This strain was identified as Streptomyces sp. by biochemical tests and 16S rDNA analysis. This actinomyceted produces various bioactive secondary metabolites. Fractionations by solvent partitioning, silica vacuum flash chromatography, and reversed-phase HPLC gave a pure cytotoxic compound. Its structure was elucidated by FAB-MS, 1H, 13C, and 2D NMR spectroscopy. This compound exhibited sigificant cytotoxicity against seven human cancer cell lines but showed no growth inhibition against various microorganisms including bacteria, fungi, and yeast.
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/31131
Bibliographic Citation
Proceedings of the convention of the pharmaceutical society of Korea, pp.246, 2006
Publisher
대한약학회
Type
Conference
Language
English
Publisher
대한약학회
Related Researcher
Research Interests

Marine Natural Products,Organic Chemistry,해양천연물,유기화학

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