믹소박테리움 Sorangium cellulosum에서 분리된 신규 세포독성 항생물질

Title
믹소박테리움 Sorangium cellulosum에서 분리된 신규 세포독성 항생물질
Alternative Title
New cytotoxic antibiotics from myxobacterium Sorangium cellulosum
Author(s)
리쥬메이; 유태경; 지옥표; 신희재; 안종웅
Publication Year
2006-04-16
Abstract
Myxobacteria are well known for the production of cytotoxic compounds with potential anticancer activities. One of the most significant examples is epothilones, which have been isolated from myxobacterium Sorangium cellulosum. These compounds have generated intense interest among many researchers owing to unusual mechanism of action and anticancer potential of these molecules. In the course of screening ofr new cytotoxic antibiotics from strains of S.cellulosum, two closely related new substances were isolated from a strain JW1059. The structures of these compounds were elucidated by spectroscopic analyses. These compounds show a weak cytotoxicity against human cancer cell lines.
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/31130
Bibliographic Citation
Proceedings of the convention of the pharmaceutical society of Korea, pp.221 - 222, 2006
Publisher
대한약학회
Type
Conference
Language
English
Publisher
대한약학회
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