해양방선균에서 분리된 신규 항암물질

Title
해양방선균에서 분리된 신규 항암물질
Alternative Title
New Cytotoxic Compounds from Marine-derived Actinomycetes
Author(s)
신희재; 김태식; 정현선; 이희승
KIOST Author(s)
Lee, Hyi Seung(이희승)
Publication Year
2006-05-29
Abstract
Actinomycetes are a well-known source of secondary metabolites having broad ranges of biological activities such as antibiotic, anticancer and immunosuppressant. However, marine actinomycetes have been largely ignored until recently [1]. As part of our ongoing program to develop the biomedical potential of marine microorganisms, we have focused considerable attention on the marine actinomycetes. We isolated more than 3,000 strains of marine actinomycetes from the marine samples such as deep sea and shallow water sediments, plants and invertebrates. We have established that about 10% of isolates show some bioactivity in our assays such as cytotoxicity, antifungal, antimicrobial, and enzyme inhibitory activities. From the bioactive isolates several new actinomycetes have been identified and a variety of bioactive molecules were characterized. We present here the discovery of cytotoxic compounds from marine-derived actinomycetes. The isolation, structure determination, and cytotoxicity of new compounds from marine actinomycetes will be presented.
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/31000
Bibliographic Citation
4th International Conference on Natural Products, pp.101, 2006
Publisher
International Society for the Development of Natural Products
Type
Conference
Language
English
Publisher
International Society for the Development of Natural Products
Related Researcher
Research Interests

Marine Natural Products,Organic Chemistry,해양천연물,유기화학

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