A New Angiogenesis Inhibitor from Streptomyces sp. Isolated from a Marine Sponge

Title
A New Angiogenesis Inhibitor from Streptomyces sp. Isolated from a Marine Sponge
Author(s)
신희재; 이희승; 권호정
KIOST Author(s)
Lee, Hyi Seung(이희승)
Publication Year
2007-02-05
Abstract
As part of our ongoing program to develop the biomedical potential of marine microorganisms, we isolated a new compound (1) having anti-angiogensis activity from the fermentation broth of a marine actinomycete. Angiogenesis, the process of new blood vessel formation, is crucial for the development and progression of pathophysiological changes associated with a variety of disorders, including various cancers, tumor metastases, and retinopathies.1 Malignant angiogenesis plays a critical role in several fatal diseases including cancer, vascular insufficiency, diabetic retinopathy, and rheumatoid arthritis by a normal delivering mechanism of oxygen and nutrients to cell and tissue. Because tumor angiogenesis caused by angiogenic inducers is the most critical factor in the growth of solid tumors,2 as well as their invasion and metastasis, early control of angiogenesis may be a promising therapeutic strategy for the related diseases.3 We present here a new angiogenesis inhibitor from marine-derived actinomycete. The isolation, structure determination, and anti-angiogenesis activity of the new compound (1) from marine actinomycete will be presented.
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/30676
Bibliographic Citation
12th International Symposium on Marine Natural Products, pp.104, 2007
Publisher
Organising Committee of International Symposium on Marine Natural Products
Type
Conference
Language
English
Publisher
Organising Committee of International Symposium on Marine Natural Products
Related Researcher
Research Interests

Marine Natural Products,Organic Chemistry,해양천연물,유기화학

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