A New Angiogenesis Inhibitor from Streptomyces sp. Isolated from a Marine Sponge
-
Title
- A New Angiogenesis Inhibitor from Streptomyces sp. Isolated from a Marine Sponge
-
Author(s)
- 신희재; 이희승; 권호정
- KIOST Author(s)
- Shin, Hee Jae(신희재); Lee, Hyi Seung(이희승)
-
Alternative Author(s)
- 신희재; 이희승
-
Publication Year
- 2007-02-05
-
Abstract
- As part of our ongoing program to develop the biomedical potential of marine microorganisms, we isolated a new compound (1) having anti-angiogensis activity from the fermentation broth of a marine actinomycete. Angiogenesis, the process of new blood vessel formation, is crucial for the development and progression of pathophysiological changes associated with a variety of disorders, including various cancers, tumor metastases, and retinopathies.1 Malignant angiogenesis plays a critical role in several fatal diseases including cancer, vascular insufficiency, diabetic retinopathy, and rheumatoid arthritis by a normal delivering mechanism of oxygen and nutrients to cell and tissue. Because tumor angiogenesis caused by angiogenic inducers is the most critical factor in the growth of solid tumors,2 as well as their invasion and metastasis, early control of angiogenesis may be a promising therapeutic strategy for the related diseases.3 We present here a new angiogenesis inhibitor from marine-derived actinomycete. The isolation, structure determination, and anti-angiogenesis activity of the new compound (1) from marine actinomycete will be presented.
-
URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/30676
-
Bibliographic Citation
- 12th International Symposium on Marine Natural Products, pp.104, 2007
-
Publisher
- Organising Committee of International Symposium on Marine Natural Products
-
Type
- Conference
-
Language
- English
- Files in This Item:
-
There are no files associated with this item.
Items in ScienceWatch@KIOST are protected by copyright, with all rights reserved, unless otherwise indicated.