LPS-Induced NO Inhibition and Antioxidant Activities of Ethanol Extracts and their Solvent Partitioned Fractions from Four Brown Seaweeds SCIE SCOPUS KCI

Cited 4 time in WEB OF SCIENCE Cited 5 time in Scopus
Title
LPS-Induced NO Inhibition and Antioxidant Activities of Ethanol Extracts and their Solvent Partitioned Fractions from Four Brown Seaweeds
Author(s)
Cho, Myoung Lae; Lee, Dong-Jin; Lee, Hyi-Seung; Lee, Yeon-Ju; You, Sang Guan
KIOST Author(s)
Lee, Hyi Seung(이희승)Lee, Yeon Ju(이연주)
Publication Year
2013-12
Abstract
The nitric oxide inhibitory (NOI) and antioxidant (ABTS and DPPH radical scavenging effects with reducing power) activities of the ethanol (EtOH) extracts and solvent partitioned fractions from Scytosiphon lomentaria, Chorda filum, Agarum cribrosum, and Desmarestia viridis were investigated, and the correlation between biological activity and total phenolic (TP) and phlorotannin (TPT) content was determined by PCA analysis. The yield of EtOH extracts from four brown seaweeds ranged from 2.6 to 6.6% with the highest yield from D. viridis, and the predominant compounds in their solvent partitioned fractions had medium and/or less polarity. The TP and TPT content of the EtOH extracts were in the ranges of 25.0-44.1 mg GAE/g sample and 0.2-4.6 mg PG/g sample, respectively, which were mostly included in the organic solvent partitioned fractions. Strong NOI activity was observed in the EtOH extracts and their solvent partitioned fractions from D. viridis and C. filum. In addition, the EtOH extract and its solvent partitioned fractions of D. viridis exhibited little cytotoxicity to Raw 264.7 cells. The most potent ABTS and DPPH radical scavenging capacity was shown in the EtOH extracts and their solvent partitioned fractions from S. lomentaria and C. filum, and both also exhibited strong reducing ability. In the PCA analysis the content of TPT had a good correlation with DPPH (r = 0.62), ABTS (r = 0.69) and reducing power (r = 0.65), however, an unfair correlation was observed between the contents of TP and TPT and NOI, suggesting that the phlorotannins might be responsible for the DPPH and ABTS radical scavenging activities.
ISSN
1738-5261
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/3058
DOI
10.1007/s12601-013-0033-y
Bibliographic Citation
OCEAN SCIENCE JOURNAL, v.48, no.4, pp.349 - 359, 2013
Publisher
KOREA OCEAN RESEARCH DEVELOPMENT INST
Subject
RADICAL-SCAVENGING ACTIVITY; NITRIC-OXIDE; REACTIVE OXYGEN; PHLOROTANNINS; ALGAE; IDENTIFICATION; INDUCTION; STRESS
Keywords
NO inhibition; phlorotannins; antioxidant activity; brown seaweeds; D. viridis
Type
Article
Language
English
Document Type
Article
Publisher
KOREA OCEAN RESEARCH DEVELOPMENT INST
Related Researcher
Research Interests

Marine Natural Products,Organic Chemistry,해양천연물,유기화학

Files in This Item:
There are no files associated with this item.

qrcode

Items in ScienceWatch@KIOST are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse