Structure of Acetylenic Alcohols from the Marine Sponge

Title
Structure of Acetylenic Alcohols from the Marine Sponge
Author(s)
이희승; 신희재; 이지혜; 박성규; 김환묵
KIOST Author(s)
Lee, Hyi Seung(이희승)
Publication Year
2007-08-19
Abstract
The biological and chemical diversity of the marine environment is difficult to measure. Especially, the marine invertebrates are proving to be a productive source of structurally unique and biologically active natural products. Since the chemical investigation of marine organisms has begun, sponges have been regarded as one of the most important organisms. In the course of our search for the bioactive secondary metabolites from marine organisms, we collected the tropical sponge Reniochalina sp. from the coast of the Weno Island, Chuuk, Federated States of Micronesia. Studies on the chemical investigation of the Reniochalina sp. led to the isolation of a variety of long-chain acetylenic alcohols. The structures of the novel compounds have been elucidated by combined spectroscopic methods including 2D NMR. Acetylenic compounds are a rapidly growing class of sponge metabolites and exhibit great structural variations in both chain length and functional groups. Some of these compounds exhibited potent cytotoxic activity in vitro against the growth of human tumor cell lines such as ACHN, NCI-H23, MDA-MB-231, HCT-15, NUGC-3, and PC-3.
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/30393
Bibliographic Citation
한국자기공명학회 31회 학술발표회, pp.26, 2007
Publisher
한국자기공명학회
Type
Conference
Language
English
Publisher
한국자기공명학회
Related Researcher
Research Interests

Marine Natural Products,Organic Chemistry,해양천연물,유기화학

Files in This Item:
There are no files associated with this item.

qrcode

Items in ScienceWatch@KIOST are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse