벤조피렌에 유도된 바다송사리의 반응유전체

Title
벤조피렌에 유도된 바다송사리의 반응유전체
Alternative Title
Benzo(a)pyrene responsive gene candidates in marine medaka
Author(s)
염승식; 우선옥
KIOST Author(s)
Yum, Seung Shic(염승식)
Publication Year
2007-11-01
Abstract
DNA microarry technology provides powerful tools for the genome-wide correlation of gene transcript levels with physiological responses and environmental changes, including global warming and anthropogenic pollution. Gene expression changes are sensitive indicator of such environmental stressors as ecotoxicogenomic view point. However, genome-wide gene expression data are only available in traditional model organisms. To overcome this limit, we introduce the heterologous hybridization to screening the benzo[a]pyrene responsive genes in marine medaka, Oryzias javanicus. As the results, we obtained fifty one differentially expressed gene candidates response to the benzo[a]pyrene (100 ppb) exposure for 24 h. Among these candidate genes, the expression level changes in 26 genes were up-regulated, and 25 genes were down-regulated. These candidate genes have great potential in use as multi-biomarkers for organic pollutants and provide a clue in mechanistic aspects of benzo[a]pyrene toxicity in aquatic animals.
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/30257
Bibliographic Citation
Molecular % Cellular Toxicology, pp.55, 2007
Publisher
Korean Society of Toxicogenomics and Toxicoproteomics
Type
Conference
Language
English
Publisher
Korean Society of Toxicogenomics and Toxicoproteomics
Related Researcher
Research Interests

Marine Genomics,Environmental Genomics,Novel biomaterials,해양생물유전체,생태환경유전체,바이오신소재

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